Assessing Causality Between Androgenetic Alopecia With Depression: A Bidirectional Mendelian Randomization Study

    Haiyang Li, Haibin Cai, Pingwei Li, Yibin Zeng, Yao Zhang
    TLDR Genetic risk for hair loss can increase depression risk, but depression doesn't increase hair loss risk.
    This study used a bidirectional Mendelian Randomization approach to examine the causal relationship between androgenetic alopecia (AGA) and depression, involving 154,988 individuals for AGA and 484,598 for depression. It found that genetic susceptibility to AGA increases the risk of developing depression (odds ratio = 1.015, P = 0.020), but depression does not significantly increase the risk of AGA. The study underscores the importance of psychosocial support for individuals with AGA due to its impact on self-image and mental health, advocating for early psychological assessment and intervention to improve quality of life. Limitations include a focus on a European population and lack of stratified analyses by gender, age, or disease duration.
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