The Comparative Effects Between Long-Term and Short-Term Treatment of Finasteride on Anxiety-Like and Depression-Like Behaviors in Early Senescent Male Rats

    October 2024 in “ Journal of Neuroscience Research ”
    Hiranya Pintana, Nattayaporn Apaijai, Titikorn Chunchai … Nipon Chattipakorn
    Studysummary In this study, researchers found that long-term treatment with 5-alpha-reductase inhibitors improved depression-like symptoms more effectively than a short-term treatment followed by withdrawal in d-galactose-induced senescent male rats, by reducing brain inflammation and oxidative stress.
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    Research cited in this study 12

    1. Anxiety and Depression-Like Behaviour Following Short-Term Finasteride Administration Is Associated With Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats Journal of psychiatric research · 2024
    2. Repeated Finasteride Administration Promotes Synaptic Plasticity and Produces Antidepressant and Anxiolytic-Like Effects in Female Rats Journal of Neuroscience Research · 2024
    3. Case Report: A Study of the Clinical Characteristics and Genetic Variants of Post-Finasteride Syndrome Patients Translational Andrology and Urology · 2022
    4. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020
    5. The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli Biomolecules · 2019
    6. Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition Psychoneuroendocrinology · 2018
    7. A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome Urology · 2018
    8. The 5α-Reductase Inhibitor Finasteride Increases Suicide-Related Aggressive Behaviors and Blocks Clozapine-Induced Beneficial Effects in an Animal Model of Schizophrenia Physiology & Behavior · 2018
    9. The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats Translational Stroke Research · 2018
    10. Finasteride Inhibited Brain Dopaminergic System and Open-Field Behaviors in Adolescent Male Rats CNS Neuroscience & Therapeutics · 2017
    11. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    12. Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients The Journal of Steroid Biochemistry and Molecular Biology · 2017