The Comparative Effects Between Long-Term and Short-Term Treatment of Finasteride on Anxiety-Like and Depression-Like Behaviors in Early Senescent Male Rats

    October 2024 in “ Journal of Neuroscience Research ”
    Hiranya Pintana, Nattayaporn Apaijai, Titikorn Chunchai, Chanisa Thonusin, Thiraphat Saengmearnuparp, Aphisek Kongkaew, Siriporn C. Chattipakorn, Nipon Chattipakorn
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    TLDR Long-term Finasteride treatment reduces depression better than short-term treatment in rats.
    This study investigated the effects of long-term versus short-term treatment with Finasteride, a 5-alpha-reductase inhibitor, on anxiety-like and depression-like behaviors in early senescent male rats induced by d-galactose. Thirty-two male Wistar rats were used, with some receiving long-term treatment (6 weeks) and others short-term treatment (2 weeks followed by a 4-week withdrawal). The study found that both treatments improved metabolic parameters and anxiety-related behaviors, but long-term treatment was more effective in reducing depression-like behaviors. This was attributed to a greater reduction in brain inflammation, oxidative stress, and brain senescence markers in the long-term treatment group.
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