Repeated Finasteride Administration Promotes Synaptic Plasticity and Produces Antidepressant and Anxiolytic-Like Effects in Female Rats

    March 2024 in “ Journal of Neuroscience Research ”
    Jose Nayana, B.S. Shankaranarayana Rao, Bettadapura N. Srikumar
    Studysummary In this study, researchers found that repeated finasteride administration in female rats led to antidepressant- and anxiolytic-like effects, potentially linked to increased estradiol and decreased corticosterone levels, with implications for neurosteroid-based treatments in women.
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    Research cited in this study 21

    1. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020
    2. Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date Drug Design Development and Therapy · 2020
    3. Finasteride and Suicide: A Postmarketing Case Series Dermatology · 2020
    4. Post-Finasteride Syndrome: An Emerging Clinical Problem Neurobiology of Stress · 2019
    5. The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli Biomolecules · 2019
    6. Sex-Specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids Cerebral cortex · 2019
    7. Long-Term Treatment with Finasteride Induces Apoptosis and Pathological Changes in Female Mice Human & Experimental Toxicology · 2019
    8. Repeated Finasteride Administration Induces Depression-Like Behavior in Adult Male Rats Behavioural Brain Research · 2019
    9. The Efficacy and Use of Finasteride in Women: A Systematic Review International Journal of Dermatology · 2019
    10. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    11. Post-Finasteride Syndrome: What to Tell Our Female Patients? British Journal of Dermatology · 2018
    12. The Risk of Dementia with the Use of 5 Alpha Reductase Inhibitors Journal of the neurological sciences · 2017
    13. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017
    14. Hormonal Therapy in Female Pattern Hair Loss International Journal of Women's Dermatology · 2017
    15. Emotional Consequences of Finasteride: Fool’s Gold American Journal of Men's Health · 2016
    16. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    17. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    18. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    19. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    20. Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice Pharmacopsychiatry · 2010
    21. Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats Hormones and Behavior · 2002

    Related research 7

    1. Similar Efficacy of Maintenance Treatment of Finasteride 1 mg Every Other Month Compared with Finasteride 1 mg Daily in Korean Men with Androgenetic Alopecia After Taking Finasteride 1 mg Daily for 1 Year Journal of The American Academy of Dermatology · 2020
    2. Clinical Observation on Acne Patients Taking Finasteride China Medical Abstract of Dermatology · 2013
    3. Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss PubMed · 2004
    4. Use of Finasteride in the Treatment of Men With Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    5. Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies PubMed · 2001
    6. Galenic-Pharmaceutical Study of Pieces of Proscar (Finasteride 5mg) and Finasteride 1mg Capsules Versus Propecia in the Treatment of Androgenetic Alopecia Hair transplant forum international · 2000
    7. Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases International Journal of Dermatology · 1995