Treatment of Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective, Real-Life Analysis in a Tertiary Center in Germany

    August 2024 in “ Journal of Clinical Medicine
    Henner Stege, Maximilian Haist, Michael Schultheis, Johannes Pawlowski, Miriam Wittmann, Stephan Grabbe, Florian Butsch
    Image of study
    TLDR Systemic treatments like hydroxychloroquine and cyclosporine A help with Lichen Planopilaris and Frontal Fibrosing Alopecia, but ongoing treatment is needed.
    This retrospective study at a German tertiary center evaluated 110 patients with Lichen Planopilaris (LPP) and Frontal Fibrosing Alopecia (FFA). It found that topical treatments were largely ineffective, with only 14% achieving stable disease. Systemic treatments, particularly hydroxychloroquine and cyclosporine A, showed significant improvement in symptoms, with response rates of 62% and 71%, respectively. However, discontinuation often led to symptom exacerbation, highlighting the need for ongoing treatment. Adverse events caused treatment cessation in 17-22% of cases. The study suggests that sustained systemic treatment is beneficial, and Janus kinase inhibitors may be effective as second-line treatments.
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results

    Related Community Posts Join

    6 / 44 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  820 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Related Research

    1 / 1 results