Irisin Promotes Hair Growth And Hair Cycle Transition By Activating The GSK-3β/β-Catenin Pathway

The study demonstrates that irisin, an exercise-derived myokine, promotes hair growth by activating the Wnt/β-catenin signaling pathway. Irisin increases the proliferation of human dermal papilla cells (hDPCs), enhances mitochondrial membrane potential, and boosts the production of growth factors essential for hair growth. It facilitates the transition into the anagen phase and increases hair follicle numbers. These effects were confirmed using cultured hDPCs and mouse models, and were negated by the Wnt-β-catenin signaling inhibitor XAV939. The findings suggest that irisin could be a potential therapeutic agent for hair loss prevention and treatment, although further research is needed to fully understand the effects of exercise-induced myokines on hair growth.