Irisin Promotes Hair Growth And Hair Cycle Transition By Activating The GSK-3β/β-Catenin Pathway

Irisin, a myokine secreted during exercise, has been shown to promote hair growth by activating the Wnt/β-catenin signaling pathway. This study utilized in vitro, ex vivo, and in vivo methods, including mouse models, to demonstrate that irisin increases proliferation, alkaline phosphatase activity, and mitochondrial membrane potential in human dermal papilla cells. It also enhances human hair shaft elongation and promotes new hair follicle generation, accelerating the transition to the anagen phase in C57BL/6 mice. The effects of irisin were inhibited by XAV939, a Wnt/β-catenin signaling inhibitor, confirming the pathway's role in irisin-mediated hair growth. These findings suggest irisin's potential as a therapeutic agent for hair loss treatment.