Hair Number Per Follicular Unit as a Marker of Treatment Response to Combined Autologous Scalp-Derived Micrografts and Allogeneic SHED-CM in Male Androgenetic Alopecia

    June 2026 in “ Journal of Cosmetic Dermatology ”
    Tomoko Kamishima, Ai Minamimura, Chie Hirabe, Junichi Taguchi
    Studysummary This study found that a combined treatment using autologous scalp‐derived micrografts and allogeneic dental pulp stem cell‐derived conditioned medium was well-tolerated and improved hair characteristics in 69.5% of patients with male androgenetic alopecia, particularly increasing hair diameter and hair number per follicular unit.
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    Research cited in this study 16

    1. Divergent Progression Pathways in Male Androgenetic Alopecia and Female Pattern Hair Loss: Trichoscopic Perspectives Journal of Cosmetic Dermatology · 2024
    2. Systematic Review of Exosome Treatment in Hair Restoration: Preliminary Evidence, Safety, and Future Directions Journal of Cosmetic Dermatology · 2023
    3. A Clinical Trial of Treating Androgenic Alopecia with Mesenchymal Stem Cell Suspension Derived from Autologous Hair Follicle Plastic and Reconstructive Surgery · 2023
    4. Trichoscopic Evaluation of Dental Pulp Stem Cell Conditioned Media for Androgenic Alopecia PubMed · 2023
    5. Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
    6. Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients JAMA Dermatology · 2022
    7. Short-Term Efficacy of Autologous Cellular Micrografts in Male and Female Androgenetic Alopecia: A Retrospective Cohort Study Clinical, Cosmetic and Investigational Dermatology · 2021
    8. Recent Progress in Understanding the Effect of Sympathetic Nerves on Hair Follicle Growth Frontiers in Cell and Developmental Biology · 2021
    9. Cell-Enriched Autologous Fat Grafts to Follicular Niche Improves Hair Regrowth in Early Androgenetic Alopecia Aesthetic Surgery Journal · 2020
    10. Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia BioMed Research International · 2020
    11. Progenitor-Cell-Enriched Micrografts as a Novel Option for the Management of Androgenetic Alopecia Journal of Cellular Physiology · 2019
    12. Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia International Journal of Molecular Sciences · 2019
    13. Dental Derived Stem Cell Conditioned Media for Hair Growth Stimulation PLOS ONE · 2019
    14. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    15. Contribution of Hair Density and Hair Diameter to the Appearance and Progression of Androgenetic Alopecia in Japanese Men British Journal of Dermatology · 2014
    16. Destruction of the Arrector Pili Muscle and Fat Infiltration in Androgenic Alopecia British Journal of Dermatology · 2014