Hair Growth-Promoting Effects of a Multi-Targeted Cosmetic Formulation Containing PYGL, DP2, and 15-PGDH Inhibitors Developed Using AI-Based DeepZema in Androgenetic Alopecia: A 24-Week Randomized Controlled Trial

    April 2026 in “ Cosmetics ”
    Sanghwa Lee, H. O. Kim, Yeon Ji Choi … Jin Hee Shin
    Studysummary In this randomized, double-blind, placebo-controlled trial, researchers found that a multi-targeted cosmetic formulation containing TrinogeniX™ significantly increased hair density and thickness in individuals with androgenetic alopecia without adverse effects, suggesting it as a potential safe and effective treatment option.
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    Research cited in this study 20

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    2. Glycogen Phosphorylase Inhibitor Promotes Hair Growth via Protecting from Oxidative Stress and Regulating Glycogen Breakdown in Human Hair Follicles Biomolecules & Therapeutics · 2024
    3. Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2024
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    6. Human Hair Follicles Operate an Internal Cori Cycle and Modulate Their Growth via Glycogen Phosphorylase Scientific Reports · 2021
    7. Anti-Inflammatory, Thrombolytic, and Hair-Growth Promoting Activity of the n-Hexane Fraction of the Methanol Extract of Leea Indica Leaves Plants · 2021
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