Frontal Fibrosing Alopecia: A New Autoimmune Entity?

    January 2019 in “ Medical Hypotheses
    Juan Esteban García-Robledo, Cristian C. Aragón, Ivana Nieto‐Aristizábal, Sara Vásquez, Claudia Montoya, Gabriel J. Tobón
    Image of study
    TLDR Frontal Fibrosing Alopecia might be an autoimmune disease.
    The document from 2019 discusses Frontal Fibrosing Alopecia (FFA), a condition primarily affecting postmenopausal Caucasian women, characterized by hairline regression and scarring. It proposes that FFA may be an autoimmune disease, citing evidence such as lymphocytic infiltrates, association with other autoimmune disorders, and response to immunomodulatory drugs. Out of 921 reported cases, only 29 were male, supporting the hypothesis that hypoandrogenism could be a factor, given FFA's prevalence in postmenopausal women with reduced DHEA serum levels. The document also notes that future research should investigate the autoimmune origin of FFA, with one study including 1083 patients and another involving biopsies from five patients with FFA.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    6 / 378 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community How essential is scalp biopsy when dealing with hair loss?

      in Treatment  6 upvotes 1 month ago
      The user experienced hair loss despite using Fin and Min for 12 years and switched to Dutasteride, RU58841, and Keto scalp serum, but shedding and itch persist. They are considering increasing Dutasteride to 2.5mg and questioning the necessity of a scalp biopsy, with mixed opinions on its usefulness.

      community Finasteride not working isnt it MPB?

      in Finasteride/Dutasteride  5 upvotes 6 months ago
      A user is concerned that finasteride isn't working for their hair loss, questioning if it's due to male pattern baldness or low iron levels. They are advised to take finasteride daily and get blood work done.

    Related Research

    4 / 4 results