Frontal Fibrosing Alopecia: A New Autoimmune Entity?

    March 2019 in “ Medical Hypotheses
    Juan Esteban García-Robledo, Cristian C. Aragón, Ivana Nieto‐Aristizábal, Sara Vásquez, Claudia Montoya, Gabriel J. Tobón
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    TLDR Frontal Fibrosing Alopecia might be an autoimmune disease.
    The document from 2019 discusses Frontal Fibrosing Alopecia (FFA), a condition primarily affecting postmenopausal Caucasian women, characterized by hairline regression and scarring. It proposes that FFA may be an autoimmune disease, citing evidence such as lymphocytic infiltrates, association with other autoimmune disorders, and response to immunomodulatory drugs. Out of 921 reported cases, only 29 were male, supporting the hypothesis that hypoandrogenism could be a factor, given FFA's prevalence in postmenopausal women with reduced DHEA serum levels. The document also notes that future research should investigate the autoimmune origin of FFA, with one study including 1083 patients and another involving biopsies from five patients with FFA.
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