February 2026 in “ACS Biomaterials Science & Engineering” In this study, researchers successfully generated hair follicle organoids using human induced pluripotent stem cells (hiPSCs) with collagen I as a microenvironment, demonstrating potential applications in hair regeneration, though fully human organoids require additional approaches.
September 2025 in “PubMed” This study describes an innovative hair restoration technique combining traditional hair transplantation with autologous stem cells, which enhances hair density and quality by optimizing transplantation results through the treatment of both native and transplanted follicles.
June 2025 in “Journal of Cosmetic Dermatology” This study reviews AI's role in aesthetic medicine, noting it enhances diagnostic accuracy and personalized treatment planning, but faces challenges like ethical concerns, algorithmic biases, and regulatory issues that need addressing for successful integration.
This review highlights that recent advancements in diagnostics and therapies, including AI-enhanced imaging, biomarker analysis, and novel treatments like low-dose oral minoxidil and JAK inhibitors, are improving the precision and customization of hair loss management.
December 2024 in “Journal of Cutaneous and Aesthetic Surgery” This review highlights recent advancements in FUE hair transplantation techniques and technologies, noting significant improvements in reducing follicle damage and increasing procedure speed, while emphasizing the need for surgeons to choose suitable devices for each patient's specific needs.
September 2024 in “Journal of Cosmetic Dermatology” This report describes ARTAS, a robotic hair transplant technology with advanced mechanical and recognition capabilities, which has gained popularity in China since 2016 due to its ease of use and efficient hair follicle harvesting.
3 citations
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August 2024 in “Journal of Cosmetic Dermatology” This study found that using ablative fractional CO₂ laser therapy combined with FUE treatment in patients with post-traumatic eyebrow scars and defects improved follicular survival rates and resulted in well-defined eyebrow shapes.
This study found that activating autophagy in hair follicle stem cells can promote hair growth by shifting their metabolism to glycolysis, while inhibiting it led to delayed hair cycle progression.
October 2022 in “Regenerative Biomaterials” This study demonstrated that fibrin hydrogels support skin-derived precursors in hair follicle neogenesis in mice, with new hair growth and regeneration of blood vessels and sebaceous glands observed.
6 citations
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October 2022 in “International Journal of Molecular Sciences” This study found that Fgf5 mutant mice exhibited longer hair, particularly in males, likely due to a prolonged anagen phase in the hair cycle.
July 2022 in “Journal of Cosmetic Dermatology” This study found that follicular unit extraction, with or without platelet rich plasma, is effective for hair restoration in cicatricial alopecia, though PRP does not significantly impact graft survival rates.
11 citations
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May 2022 in “Chinese medicine” This study found that Alpinetin, applied topically in C57BL/6J mice, promoted hair regeneration by activating hair follicle stem cells through Wnt signaling, extending the anagen phase and increasing hair shaft length, with no cytotoxicity observed in keratinocytes and fibroblasts.
April 2022 in “Journal of Cosmetic Dermatology” In this study, combining platelet-rich plasma and platelet gel treatments significantly reduced hair loss and increased hair density and diameter in patients with resistant androgenic alopecia, leading to high patient satisfaction.
2 citations
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October 2021 in “Experimental Cell Research” This study found that injectable platelet-rich fibrin (i-PRF) enhances hair follicle regeneration in vitro by promoting human dermal papilla cell proliferation, migration, and trichogenic inductivity, with varying effects depending on concentration.
6 citations
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October 2021 in “Indian Journal of Plastic Surgery” In this study, eyebrow restoration using FUE-harvested single hair follicle grafts was explored, emphasizing the importance of donor hair selection, placement technique, and postoperative care in achieving optimal results, while highlighting challenges such as scarring and skin perfusion.
1 citations
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August 2021 in “Dermatologic Surgery” This study reviewed 31 men with androgenetic alopecia who underwent hair transplantation using a robotic recipient site creation device, finding it to be as fast and consistent as manual methods and demonstrating high safety and patient satisfaction.
12 citations
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April 2020 in “Facial Plastic Surgery Clinics of North America” This article discusses potential complications in hair restoration surgery and emphasizes the importance of thorough planning and patient participation in reducing risks, but reports no new clinical findings.
3 citations
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April 2020 in “Facial Plastic Surgery Clinics of North America” This review discusses the increasing demand for facial hair transplantation in hair restoration, noting its benefits and the natural-appearing results achieved through modern techniques, but it reports no new clinical results.
4 citations
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January 2020 in “Journal of Cutaneous and Aesthetic Surgery” This case report highlights keloid formation as a rare complication at the donor site after follicular unit extraction hair transplantation, suggesting practitioners should be aware of procedure-associated risks.
47 citations
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December 2019 in “Biomaterials” This study demonstrated effective delivery of CRISPR/Cas9 components to dermal papilla cells in androgenic alopecia animals using ultrasound-activated nanoparticles, resulting in specific gene editing and hair growth recovery.
33 citations
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January 2018 in “International Journal of Biological Sciences” This study demonstrates the use of the CRISPR-Cas9 system to successfully edit the EDAR gene in Cashmere goats, resulting in goats with distinct hair follicle characteristics.
102 citations
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April 2014 in “PloS one” In this study, Wharton’s Jelly Mesenchymal Stem Cells, cultured with human platelet lysate, showed enhanced wound-healing capabilities and multilineage differentiation potential, distinguishing them from bone marrow-derived stem cells and presenting exciting prospects for regenerative medicine.
52 citations
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February 2012 in “PloS one” This study found that the absence of Ctip2 in epidermal keratinocytes led to impaired wound healing in mice, affecting cell migration, proliferation, and hair follicle stem cell maintenance.
28 citations
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September 2011 in “Stem Cell Reviews and Reports”
