Evaluation of the Relationship Between Serum G Protein-Coupled Estrogen Receptors (GPER-1) Levels and the Severity and Duration of the Disease in Patients with Androgenetic Alopecia: A Case-Control Study

Androgenetic alopecia is a common hair loss condition influenced by various factors and linked to psychosocial and cardiovascular issues.

Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.

Hair loss in adults is linked to heart disease risk factors like unhealthy blood fats, lack of exercise, and alcohol use. It's also slightly more common in people with metabolic syndrome. As people age, hair loss gets worse. In men, severe hair loss is tied to high blood pressure and a larger waist. In women, it's tied to higher body weight. People with hair loss should be checked for unhealthy blood fats and advised to avoid alcohol and inactivity.

Alopecia patients have less GPER-1, which might affect hair loss.

DHT stops hair regrowth in mice, similar to human hair loss.

Inflammation affects hair loss; anti-inflammatory treatments may help.

Serum biomarkers like insulin-like growth factor-1 and vitamin D may help diagnose androgenetic alopecia.

Inflammation and fibrosis are not significantly different in pattern hair loss compared to controls.

Hair loss treatments work better with lifestyle changes.

The effects of estrogen on human scalp hair growth are unclear and need more research.

WNT7A gene expression is higher in early stages of androgenetic alopecia, showing the role of WNT pathway, apoptosis, and inflammation in the disorder.

Oxidative stress increases in early hair loss, and family history plays a role; antioxidants may help future treatments.

Multiple treatments work best for hair loss.

Hair loss in women links to inflammation around hair follicles.

Asian hair loss differs from Europeans; consider individual needs and psychological well-being for treatment.

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

Estrogen affects hair growth and skin cell multiplication.

Antimicrobial lotion reduces inflammation and increases hair density in hair loss patients.

Minoxidil speeds up hair growth in rats without prolonging growth phase.