Development and Evaluation of Finasteride Niosomes Targeting Hair Follicles for Androgenic Alopecia Management

    Fei Liu, Feng Guo, Desheng Liang, Fulin Li, Yating Cao, Mengqi Chen, Jianjun Xu, Xinliang Liu, Haijun Zhong
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    TLDR Finasteride niosomes were developed and found to be effective in treating hair loss, with better results than commercial minoxidil, and could be a promising topical treatment for hair loss.
    The study developed and evaluated finasteride niosomes (FIN-NIS) as a dermal delivery system for the treatment of androgenetic alopecia (AGA), a common hair loss disorder. Finasteride, an oral drug that inhibits the conversion of testosterone to dihydrotestosterone, has been used to treat AGA, but long-term oral administration can lead to serious systemic side effects. The researchers found that FIN-NIS enhanced finasteride permeation and retention, particularly increasing drug concentration in hair follicles. The therapeutic efficacy of FIN-NIS on testosterone-induced AGA mice was higher than that of commercial minoxidil in terms of hair regrowth and anagen restoration. Therefore, FIN-NIS could be a promising dermal topical delivery system for the treatment of AGA.
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      community Post FUE finasteride - moved from oral to topical

      in Finasteride  90 upvotes 1 week ago
      The user switched from oral to topical finasteride with minoxidil after a hair transplant and is experiencing increased hair growth in unexpected areas like eyebrows and sideburns. They are seeking feedback from others with similar experiences.

      community Temporary alternative to finasteride?

      in Finasteride  100 upvotes 1 month ago
      A 23-year-old male plans to temporarily stop finasteride to donate plasma for financial reasons and seeks alternative hair loss treatments like minoxidil, ketoconazole, or RU58841 during this period. He is open to suggestions to prevent further hair loss until he can resume finasteride.

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