Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

    February 2023 in “ International Journal of Molecular Sciences ”
    Kaja Troha, Domen Vozel, Matevž Arko, Apolonija Bedina Zavec, Drago Dolinar, Matej Hočevar, Zala Jan, Matic Kisovec, Boštjan Kocjančič, Ljubiša Pađen, Manca Pajnič, Samo Penič, Anna Romolo, Neža Repar, Vesna Spasovski, Nejc Steiner, Vid Šuštar, Aleš Iglič, Damjana Drobne, Ksenija Kogej, Saba Battelino, Veronika Kralj-Iglič
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    TLDR Autologous Platelet and Extracellular Vesicle-Rich Plasma (PVRP) has potential in enhancing tissue regeneration and improving hair conditions, but its effectiveness varies due to individual differences.
    The review discusses the therapeutic potential of Autologous Platelet and Extracellular Vesicle-Rich Plasma (PVRP), a complex substance used in various medical fields. PVRP contains bioactive molecules like growth factors, amino acids, hormones, and more, which are involved in healing mechanisms. Extracellular vesicles (EVs), small particles shed from activated platelets, play a crucial role in cellular signaling and mediate communication between cells. The effectiveness of PVRP treatment varies due to differences in patients' plasma composition, influenced by factors such as age, sex, diet, and physical activity. PVRP has shown potential in enhancing tissue regeneration in various medical fields, including maxillofacial surgery, dermatology, ophthalmology, and more. In the treatment of alopecia, PVRP has been found to significantly improve hair density, hair count, hair shedding, and hair diameter in patients with mild conditions. However, more randomized comparative studies are needed to confirm these findings. The review emphasizes the need for individual consideration of PVRP products in clinical use due to the complexity of interactions influencing PVRP composition.
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