Alopecia Secondary to Hyaluronic Acid Injection: A Case Report and Literature Review

June 2025 in “ Clinical Cosmetic and Investigational Dermatology ”

Lingling Jia, Jiachao Xiong, Changjiang Zhao, Hua Jiang, Yufei Li

hyaluronic acid alopecia Concentrated Growth Factor microneedling minoxidil vascular occlusion ischemia hyaluronidase HA CGF MN Rogaine HAase

TLDR Hyaluronic acid injections can cause temporary hair loss, but hair can regrow with early treatment.

This document discusses a case of alopecia in a 23-year-old woman following hyaluronic acid (HA) injections, with complete hair regrowth achieved after four months using Concentrated Growth Factor (CGF), microneedling (MN), and minoxidil. A literature review identified 19 similar cases, mostly in females, with alopecia occurring 1 to 4 weeks post-injection, primarily in the temple region. The study suggests that HA-induced alopecia may result from vascular occlusion and ischemia, emphasizing the importance of early intervention with hyaluronidase (HAase) and a multimodal treatment approach. It highlights the need for preventive measures and further research to confirm these findings in larger studies.

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