A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention

    September 2017 in “ Oncologist ”
    Christopher Dunnill, W. Al-Tameemi, Andrew Collett … Nikolaos T. Georgopoulos
    Studysummary This source reports that scalp cooling is currently the only safe and FDA-cleared method to potentially reduce chemotherapy-induced hair loss, with about a 50% chance of maintaining sufficient hair to avoid needing a wig.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on theoncologist.onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 49

    1. Permanent Diffuse Alopecia After Hematopoietic Stem Cell Transplantation in Childhood Bone Marrow Transplantation · 2017
    2. Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition Journal of Investigative Dermatology · 2016
    3. Results of Scalp Cooling During Anthracycline-Containing Chemotherapy Depend on Scalp Skin Temperature Breast · 2016
    4. The Use of Scalp Cooling for Chemotherapy-Induced Hair Loss British journal of nursing · 2016
    5. Simulation of Scalp Cooling by External Devices for Prevention of Chemotherapy-Induced Alopecia Journal of thermal biology · 2015
    6. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    7. Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles Journal of Investigative Dermatology · 2015
    8. The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia Skin Pharmacology and Physiology · 2015
    9. The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia Oncology Research and Treatment · 2015
    10. Differential Expression and Functionality of ATP-Binding Cassette Transporters in the Human Hair Follicle British Journal of Dermatology · 2014
    11. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    12. Testing Chemotherapeutic Agents in the Feather Follicle Identifies a Selective Blockade of Cell Proliferation and a Key Role for Sonic Hedgehog Signaling in Chemotherapy-Induced Tissue Damage Journal of Investigative Dermatology · 2014
    13. Efficacy of Interventions for Prevention of Chemotherapy-Induced Alopecia: A Systematic Review and Meta-Analysis International journal of cancer · 2014
    14. Parathyroid Hormone-Related Peptide and the Hair Cycle: Is It the Agonists or the Antagonists That Cause Hair Growth? Experimental Dermatology · 2014
    15. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    16. Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior Cold Spring Harbor Perspectives in Medicine · 2014
    17. Regenerative Medicine and Hair Loss: How Hair Follicle Culture Has Advanced Our Understanding of Treatment Options for Androgenetic Alopecia Regenerative Medicine · 2013
    18. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    19. Chemotherapy-Induced Hair Loss PubMed · 2010
    20. Permanent Chemotherapy-Induced Alopecia: Case Report and Review of the Literature Journal of The American Academy of Dermatology · 2010
    21. Irreversible And Severe Alopecia Following Docetaxel Or Paclitaxel Cytotoxic Therapy For Breast Cancer British journal of dermatology/British journal of dermatology, Supplement · 2009
    22. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    23. Modulation of Chemotherapy-Induced Human Hair Follicle Damage by 17-Beta Estradiol and Prednisolone: Potential Stimulators of Normal Hair Regrowth by Dystrophic Catagen Promotion? Journal of Investigative Dermatology · 2008
    24. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    25. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    26. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    27. Protection Against Chemotherapy-Induced Alopecia Pharmaceutical Research · 2006
    28. Chemotherapy Targets the Hair Follicle Vascular Network but Not the Stem Cells Journal of Investigative Dermatology · 2006
    29. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    30. Therapeutic Strategies for Treating Hair Loss Drug Discovery Today: Therapeutic Strategies · 2006
    31. Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor Alpha Is Checked by ER Beta Signaling Endocrinology · 2005
    32. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004
    33. Inherited Disorders of the Skin in Humans and Mice: From Development to Differentiation The International Journal of Developmental Biology · 2004
    34. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control Journal of Investigative Dermatology · 2003
    35. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    36. Inhibitory Effect of M50054, a Novel Inhibitor of Apoptosis, on Anti-Fas-Antibody-Induced Hepatitis and Chemotherapy-Induced Alopecia European Journal of Pharmacology · 2001
    37. Hair and Cancer Chemotherapy: Consequences and Nursing Care - A Literature Study European Journal of Cancer Care · 2001
    38. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    39. Permanent Alopecia Following Chemotherapy and Bone Marrow Transplantation Australasian Journal of Dermatology · 2000
    40. Efficient Delivery of Transgenes to Human Hair Follicle Progenitor Cells Using Topical Lipoplex Nature biotechnology · 2000
    41. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro Journal of Investigative Dermatology · 1998
    42. Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    43. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    44. The Protective Role of the Immunomodulator AS101 Against Chemotherapy-Induced Alopecia: Studies on Human and Animal Models International Journal of Cancer · 1996
    45. Protection Against Cytosine Arabinoside-Induced Alopecia by Minoxidil in a Rat Animal Model International Journal of Dermatology · 1995
    46. Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone PubMed · 1994
    47. Chemotherapy-Induced Alopecia Southern Medical Journal · 1993
    48. Treatment with ImuVert and N-Acetylcysteine Protects Rats from Cyclophosphamide and Cytarabine-Induced Alopecia Cancer investigation · 1992
    49. Human Hair Growth In Vitro Journal of Cell Science · 1990

    Related research 2

    1. The Use of Scalp Cooling for Chemotherapy-Induced Hair Loss British journal of nursing · 2016
    2. Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions Toward Clinical Reality ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2016