Prevention of Chemotherapy Drug-Mediated Human Hair Follicle Damage: Combined Use of Cooling with Antioxidant Suppresses Oxidative Stress and Prevents Matrix Keratinocyte Cytotoxicity

    July 2025 in “ Frontiers in Pharmacology ”
    Khalidah Ibraheem, Adrian L. Smith, Andrew Collett, Nikolaos T. Georgopoulos
    Studysummary This study found that cooling combined with antioxidants can improve scalp cooling effectiveness in preventing chemotherapy-induced alopecia by maintaining hair follicle viability and function.
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    Research cited in this study 17

    1. Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes Against Paclitaxel-Induced Damage Ex Vivo Journal of Investigative Dermatology · 2023
    2. Cooling-Mediated Protection from Chemotherapy Drug-Induced Cytotoxicity in Human Keratinocytes by Inhibition of Cellular Drug Uptake PLoS ONE · 2020
    3. Identifying the Supportive Care Needs of Men and Women Affected by Chemotherapy-Induced Alopecia: A Systematic Review Journal of cancer survivorship · 2020
    4. Scalp Cooling to Prevent Chemotherapy-Induced Alopecia Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2020
    5. CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia EMBO Molecular Medicine · 2019
    6. Chemotherapy-Induced Hair Loss: The Use of Biomarkers for Predicting Alopecic Severity and Treatment Efficacy Biomarker Insights · 2019
    7. Persistent Major Alopecia Following Adjuvant Docetaxel for Breast Cancer: Incidence, Characteristics, and Prevention with Scalp Cooling Breast Cancer Research and Treatment · 2018
    8. A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention Oncologist · 2017
    9. Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition Journal of Investigative Dermatology · 2016
    10. Results of Scalp Cooling During Anthracycline-Containing Chemotherapy Depend on Scalp Skin Temperature Breast · 2016
    11. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    12. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
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