Bottom-Up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration

    December 2017 in “ Advanced Healthcare Materials ”
    Jin Wang, Yong Miao, Yong Huang … Malcolm Xing
    Studysummary This study reports that using nanogel and layer-by-layer self-assembly to encapsulate single dermal papilla cells can form cell spheroids that regenerate hair follicles successfully in a hair follicle regeneration model.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 12

    1. Rapid Formation of Cell Aggregates and Spheroids Induced by a Smart Boronic Acid Copolymer ACS Applied Materials & Interfaces · 2016
    2. Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration ACS Applied Materials & Interfaces · 2016
    3. Cytokine Loaded Layer-By-Layer Ultrathin Matrices to Deliver Single Dermal Papilla Cells for Spot-By-Spot Hair Follicle Regeneration Journal of Materials Chemistry B · 2015
    4. Antimicrobial Peptide Lysozyme Has the Potential to Promote Mouse Hair Follicle Growth In Vitro Acta histochemica · 2015
    5. Controllable Production of Transplantable Adult Human High-Passage Dermal Papilla Spheroids Using 3D Matrigel Culture Tissue engineering. Part A · 2014
    6. Neonatal Murine Skin-Derived Cells Transplanted Using a Mini-Chamber Model Produce Robust and Normal Hair Journal of Tissue Engineering and Regenerative Medicine · 2013
    7. Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials · 2012
    8. Large-Scale Cultivation of Transplantable Dermal Papilla Cellular Aggregates Using Microfabricated PDMS Arrays Acta Biomaterialia · 2010
    9. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    10. Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration Biomaterials · 2008
    11. Microencapsulated Human Hair Dermal Papilla Cells: A Substitute for Dermal Papilla? Archives of Dermatological Research · 2008
    12. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002

    Related research 1

    1. Bottom-Up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration Advanced Healthcare Materials · 2017