The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring

    March 2023 in “ Pharmaceutics ”
    Vera Vorstandlechner, Dragan Copic, Katharina Klas … Michael Mildner
    Studysummary This study found that PBMCsec has anti-fibrotic effects on mouse and human skin scars by regulating pro-fibrotic gene expression and inhibiting myofibroblast differentiation and elastic fiber breakdown.
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    Research cited in this study 8

    1. Advanced Nanocarrier- and Microneedle-Based Transdermal Drug Delivery Strategies for Skin Diseases Treatment Theranostics · 2022
    2. Scars Or Regeneration? Dermal Fibroblasts As Drivers Of Diverse Skin Wound Responses International Journal of Molecular Sciences · 2020
    3. Toward Understanding Scarless Skin Wound Healing and Pathological Scarring F1000Research · 2019
    4. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    5. Recent Understandings of Biology, Prophylaxis, and Treatment Strategies for Hypertrophic Scars and Keloids International journal of molecular sciences · 2018
    6. Skin Wound Healing in Humans and Mice: Challenges in Translational Research Journal of Dermatological Science · 2017
    7. Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration Mediators of Inflammation · 2017
    8. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015