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    Plant Exosome Injections for Hair Follicle Proliferation and Immune Modulation: An Immunohistochemical Study

    July 2026 in “ Plastic & Reconstructive Surgery Global Open ”
    Noury Adel, Jack Kolenda, Youn Kyong Jo … Ida Vega Thulesen
    Studysummary This study found that intradermal injections of plant-derived exosomes in adults with early-stage alopecia increased stem cell activity, activated Wnt signaling pathways, and reduced certain immune cell populations, providing insights into their role in hair follicle regeneration and suggesting potential for hair restoration therapy.
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    Research cited in this study 14

    1. LncRNA RP11-818O24.3 Regulates Proliferation and Differentiation of Hair Follicle Stem Cells by Targeting FGF2/PI3K/AKT Pathway PLoS ONE · 2025
    2. A Meta-Analysis of Chemokines in Alopecia Areata: Recruiting Immune Cells Toward the Hair Follicle Frontiers in Immunology · 2025
    3. From Mechanisms to Therapies: Current Advances and Breakthroughs in Alopecia Areata Immunopathology Frontiers in Immunology · 2025
    4. An Exosome Regenerative Complex Plus Microneedling Promotes Hair Growth in Subjects With Self-Perceived Thinning Hair PubMed · 2025
    5. Recent Advances in the Role of Fibroblast Growth Factors in Hair Follicle Growth Biomolecules · 2025
    6. A Hair-Follicle Reconstructed In Vitro Immunocompetent Skin Model for Prediction of the Sensitizing Potential of Chemicals Archives of Toxicology · 2025
    7. Prostaglandin F2α Stimulates Growth of Human Intermediate Hair Follicles in Ex Vivo Organ Culture with Potential Clinical Relevance Frontiers in Physiology · 2025
    8. Therapeutic Potential of Isoproterenol in Androgenetic Alopecia: Activation of Hair Follicle Stem Cells via the PI3K/AKT/β-Catenin Signaling Pathway Stem Cell Research & Therapy · 2025
    9. Revolutionary Approaches to Hair Regrowth: Follicle Neogenesis, Wnt/β-Catenin Signaling, and Emerging Therapies Cells · 2025
    10. Platelet-Derived Extracellular Vesicles Promote Hair Follicle Growth Through Beta-Catenin Signaling Pathway Platelets · 2025
    11. Platelet-Rich Plasma-Derived Exosomes Stimulate Hair Follicle Growth Through Activation of the Wnt/β-Catenin Signaling Pathway Regenerative Therapy · 2025
    12. Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives Stem Cell Research & Therapy · 2025
    13. Exosomes for Treating Hair Loss: A Review of Clinical Studies Dermatologic Surgery · 2024
    14. Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024