Hair Follicle Stem Cell Progeny Heal Blisters While Pausing Skin Development

April 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Yoshihiko Fujimura, Mika Watanabe, Katsutoshi Ohno, Yasuaki Kobayashi, Shota Takashima, Hideki Nakamura, Hideyuki Kosumi, Yunan Wang, Yosuke Mai, Andrea Lauria, Valentina Proserpio, Hideyuki Ujiie, Hiroaki Iwata, Wataru Nishie, Masaharu Nagayama, Salvatore Oliviero, Giacomo Donati, Hiroshi Shimizu, Ken Natsuga

hair follicles epidermis skin morphogenesis lineage tracing cell proliferation junctional zone stem cells interfollicular stem cells wound healing skin blistering diseases HFs skin development blisters

Studysummary In this study, researchers found that in growing skin tissue, epidermal wound healing occurs at the expense of normal skin development, as it impairs hair follicle growth and does not activate tissue morphogenesis genes.

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research Sox11 And Sox4 Drive The Reactivation Of An Embryonic Gene Program During Murine Wound Repair

87 citations , September 2019 in “Nature Communications”

In this study, researchers identified that upon tissue injury in a mouse model, epidermal cells at the wound edge convert to an embryonic-like state with SOX11 and SOX4 playing a central role in modulating epidermal development and cell migration genes.

research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing

211 citations , November 2018 in “Nature Cell Biology”

This article discusses the coordinated roles of different epidermal stem cells and other cell types in the skin's wound healing process and reports no new experimental results.

research Skin Cell Heterogeneity in Development, Wound Healing, and Cancer

211 citations , May 2018 in “Trends in cell biology”

This review explores recent insights into the diverse cell populations involved in skin development, homeostasis, wound healing, and cancer progression but reports no new results.

research Life Before and Beyond Blistering: The Role of Collagen XVII in Epidermal Physiology

63 citations , March 2018 in “Experimental Dermatology”

This review explores the physiological roles of collagen XVII in the epidermis, its involvement in stem cell maintenance, and its connections with signaling pathways, but it reports no new results.

research Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis

124 citations , July 2017 in “eLife”

This study found that COL17 deficiency in neonatal mice causes abnormal skin cell proliferation due to disrupted Wnt signaling, while replenishing or overexpressing COL17 can reverse this effect in both neonatal and aged skin.

research Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties

143 citations , May 2017 in “Nature cell biology”

This study found that the transcription factor Gata6 regulates the sebaceous duct lineage identity and plays a crucial role in epidermal wound healing by enabling dedifferentiation and broader lineage capabilities in post-mitotic cells.

research Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis

363 citations , March 2017 in “Nature Communications”

This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations , February 2016 in “Science”

This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.

research Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

87 citations , January 2016 in “Development”

This study suggests that the postnatal loss of hair follicle formation in wounds may be due to elevated Wnt/β-catenin activation in the dermis, affecting fibroblast function in mice.

research Stem Cell Heterogeneity and Plasticity in Epithelia

129 citations , May 2015 in “Cell Stem Cell”

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research Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

283 citations , February 2011 in “Cell stem cell”

COL17A1 is crucial for preventing hair graying and loss by supporting hair and pigment stem cells.

research Alopecia in Epidermolysis Bullosa

21 citations , November 2009 in “Dermatologic Clinics”

This review discusses hair abnormalities in various epidermolysis bullosa subtypes and reports no new clinical findings.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.