Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors

    January 2002 in “ Development ”
    Catherin Niemann, David M. Owens, Jörg Hülsken … Fiona M. Watt
    Studysummary In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.
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    Research cited in this study 11

    1. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    2. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    3. Expression of Involucrin in Normal, Hyperproliferative, and Neoplastic Mouse Keratinocytes Experimental Dermatology · 2000
    4. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    5. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    6. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    7. Regulation of a Hair Follicle Keratin Intermediate Filament Gene Promoter Journal of Cell Science · 1998
    8. Splitting Hairs: Molecular Mechanisms of Hair and Feather Development Cell · 1998
    9. Genomic Characterization of the Human Type I Cuticular Hair Keratin hHa2 and Identification of an Adjacent Novel Type I Hair Keratin Gene hHa5 Journal of Investigative Dermatology · 1996
    10. The Secret Life of the Hair Follicle Trends in genetics · 1992
    11. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986

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