Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth Ex Vivo

    January 2019 in “ Skin Pharmacology and Physiology ”
    Jennifer E. Hundt, Stephanie N. Sass, Wolfgang Funk … Ralf Paus
    Studysummary This study found that inhibiting mineralocorticoid receptor signaling in female human hair follicles may promote hair growth by extending the anagen phase and encouraging keratinocyte proliferation.
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    Research cited in this study 7

    1. Mineralocorticoid Receptor Antagonists: A New Sprinkle of Salt and Youth Journal of Investigative Dermatology · 2016
    2. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    3. Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia International Journal of Nanomedicine · 2014
    4. Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin PLOS ONE · 2013
    5. The Mineralocorticoid Receptor as a Novel Player in Skin Biology: Beyond the Renal Horizon? Experimental Dermatology · 2009
    6. Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia American Journal of Pathology · 2007
    7. Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial The Journal of Clinical Endocrinology and Metabolism · 2000