Optimal Stimulation Toward the Dermal Papilla Lineage Can Be Promoted by Combined Use of Osteogenic and Adipogenic Inducers

    November 2019 in “ FEBS open bio ”
    Taheruzzaman Kazi, Ichitaro Niibe, Akio Nishikawa, Takashi Matsuzaki
    Studysummary This study found that stimulating dermal papilla cells with specific adipo-osteogenic factors and growth factors helped maintain their viability and restored their hair-forming activity in vitro.
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    The study concluded that the combined use of osteogenic and adipogenic inducers, along with FGF2 and PDGF-AA, significantly promoted the optimal stimulation of dermal papilla cells (DPCs) toward the dermal papilla lineage, which is essential for hair follicle development and hair growth. This combination enhanced the expression of key dermal papilla markers, maintained spheroid structure, and improved hair-forming activity in vitro and in grafted nude mice. The findings suggested a potential therapeutic approach for hair loss and alopecia by effectively targeting and preserving the hair-regenerative properties of DPCs.
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