Fibroblasts in Diabetic Foot Ulcers

    February 2024 in “ International Journal of Molecular Sciences ”
    Francesca Voza, Carlos Theodore Huerta, Nga Le … Omaida C. Velázquez
    Studysummary This study highlights the crucial, multifaceted roles of fibroblasts in wound healing and various diseases, including their dysregulation in diabetic foot ulcers, underscoring the need for targeted therapies to address complications and morbidity from such chronic conditions.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 18

    1. Single-Cell Analysis Reveals Distinct Functional Heterogeneity of CD34+ Cells in Anagen and Diabetic Wounds Biochemical and Biophysical Research Communications · 2022
    2. Fibroblasts: Immunomodulatory Factors in Refractory Diabetic Wound Healing Frontiers in Immunology · 2022
    3. Beta-Catenin Signaling Evokes Hair Follicle Senescence by Accelerating the Differentiation of Hair Follicle Mesenchymal Progenitors Frontiers in Cell and Developmental Biology · 2022
    4. Scars Or Regeneration? Dermal Fibroblasts As Drivers Of Diverse Skin Wound Responses International Journal of Molecular Sciences · 2020
    5. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    6. Lineage Identity and Location Within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin Journal of Investigative Dermatology · 2018
    7. Fibroblasts and Wound Healing: An Update Regenerative Medicine · 2018
    8. Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner Journal of Investigative Dermatology · 2018
    9. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    10. Subpopulations of Dermal Skin Fibroblasts Secrete Distinct Extracellular Matrix: Implications for Using Skin Substitutes in the Clinic British Journal of Dermatology · 2017
    11. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    12. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    13. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages Nature Communications · 2016
    14. Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing British Journal of Dermatology · 2015
    15. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    16. Wnt Signaling and Injury Repair Cold Spring Harbor Perspectives in Biology · 2012
    17. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    18. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007