UV Radiation, Vitamin D, and Epidermal Carcinogenesis

    December 2009 in “ Expert review of dermatology ”
    Daniel D. Bikle
    Studysummary This article reviews evidence suggesting that vitamin D and its metabolite may help protect against nonmelanoma skin cancer, but reports no new empirical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 8

    1. Genetic Architecture of Mouse Skin Inflammation and Tumor Susceptibility Nature · 2009
    2. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    3. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008
    4. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    5. Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse Journal of cellular physiology · 2006
    6. FOXE1, A New Transcriptional Target Of GLI2, Is Expressed In Human Epidermis And Basal Cell Carcinoma Journal of Investigative Dermatology · 2004
    7. Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    8. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000