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    Chronic Stress Suppresses the Expression of Cutaneous Hypothalamic-Pituitary-Adrenocortical Axis Elements and Melanogenesis

    May 2014 in “ PLoS ONE ”
    Silin Pang, Huali Wu, Qian Wang … Jing Shang
    Studysummary This study suggests that chronic stress can lead to decreased skin pigmentation in mice by disrupting the skin's HPA axis, potentially making stress a risk factor for depigmentation.
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    Research cited in this study 7

    1. Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice PLoS ONE · 2013
    2. Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin Journal of Investigative Dermatology · 2010
    3. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    4. Corticotropin-Releasing Hormone and the Skin Frontiers in bioscience · 2006
    5. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    6. Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    7. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004