December 2023 in “Journal of the Endocrine Society” In this study, the researchers found that glucocorticoid receptor activation may influence glucose metabolism, with preventive GR antagonist treatment reducing hyperglycemia and restoring glucose tolerance in a PCOS mouse model.
8 citations
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October 2016 in “Journal of Investigative Dermatology” This study found that using mineralocorticoid receptor antagonists with glucocorticoid therapy improved wound healing in diabetic animals by enhancing keratinocyte proliferation and epithelialization.
9 citations
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June 2021 in “International Journal of Pharmaceutics” This study found that polymeric micelle nanocarriers delivered pharmacologically relevant amounts of spironolactone to the epidermis and upper dermis, with higher delivery to pilosebaceous units, suggesting potential for treating glucocorticoid-induced impaired wound healing and pilosebaceous androgen-related skin diseases.
January 2022 in “Figshare” This study suggests that stress-associated hair loss may occur due to increased androgen receptor expression and activity induced by dexamethasone in human and mouse dermal papilla cells.
54 citations
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December 2007 in “Best Practice & Research Clinical Endocrinology & Metabolism” This review discusses the potential of targeting glucocorticoid action as a treatment strategy for obesity and type-2 diabetes, highlighting promising animal study results but reports no new clinical findings.