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Research

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Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor

research Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor

11 citations , May 2015 in “Stem Cells Translational Medicine”

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

Supplementary Material for: Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells

research Supplementary Material for: Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells

January 2022 in “Figshare”

Dexamethasone increases androgen receptor activity in scalp cells, which might explain stress-related hair loss.

research Chronic Stress Suppresses the Expression of Cutaneous Hypothalamic-Pituitary-Adrenocortical Axis Elements and Melanogenesis

40 citations , May 2014 in “PLoS ONE”

Chronic stress can reduce skin pigmentation.

research Progesterone Promotes the Survival of Newborn Neurons in the Dentate Gyrus of Adult Male Mice

January 2010 in “Acta Universitatis Medicinalis Nanjing”

Progesterone helps adult male mice's brain cells survive and improves learning and memory.

research Inducible Cre-Mediated N-Ras Activation and PTEN Inactivation in Transgenic Mouse Melanocytes Requires Keratinocyte Hyperplasia to Elicit a Melanocyte Pathology

January 2005 in “Enlighten: Publications (The University of Glasgow)”

Melanocyte pathology requires keratinocyte hyperplasia and regulation dysfunction.

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Community Join

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community The story of RU58841/ PSK3841

Typical-Promise-3001 in Research 622 upvotes 1 year ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community 9 months Finasteride, minoxidil and Derma Roller. I’m not fully satisfied with my results so I might start taking Dutasteride

in Progress Pictures 101 upvotes 2 years ago

A user shared their 9-month hair regrowth progress using Finasteride, Minoxidil, and a Derma Roller, expressing dissatisfaction with the results and considering Dutasteride. Commenters generally praised the user's results, suggesting they have a full head of hair and advising to continue the current treatment or wait longer before changing it.

community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 2 years ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community Research behind RU-58642? Has anyone heard of this?

in Research/Science 1 upvotes 9 months ago

RU-58642 is a powerful anti-androgen that was not developed further, possibly due to safety concerns or financial reasons. RU58841 is a topical alternative, but it is less effective than finasteride and dutasteride, and its long-term effects are not well-studied.

community Laser Diode Cap, I already use Oral Fin, Topical Min 5%, Nizoral and Microneedling

in Treatment 1 upvotes 4 months ago

The user is seeking advice on maximizing hair growth while using oral finasteride, topical minoxidil, Nizoral, and microneedling, and is considering adding a laser diode cap, topical finasteride, retinol, and caffeine. Suggestions include using tretinoin with minoxidil for better absorption, switching to dutasteride, and considering RU58841 or pyrilutamide.

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