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Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor

research Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor

11 citations, May 2015 in “Stem Cells Translational Medicine”

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

Supplementary Material for: Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells

research Supplementary Material for: Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells

January 2022 in “Figshare”

Dexamethasone increases androgen receptor activity in scalp cells, which might explain stress-related hair loss.

research Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

49 citations, October 2009 in “Cancer research”

Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations, July 2012 in “Journal of Investigative Dermatology”

Wnt ligands are crucial for hair growth and repair.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations, May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

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community The story of RU58841/ PSK3841

in Research 622 upvotes 4 months ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 11 months ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community I’ve been on dutesteride and oral minoxidil for two years now and I’ve only lost ground… 25m What should I do?

in Treatment 33 upvotes 8 months ago

A user on dutasteride and oral minoxidil for two years has experienced worsening hair loss and an itchy scalp. Suggestions include increasing medication doses, trying other treatments like RU58841, getting a scalp biopsy, and addressing potential inflammation through diet and topical treatments.

community 9 months Finasteride, minoxidil and Derma Roller. I’m not fully satisfied with my results so I might start taking Dutasteride

in Progress Pictures 101 upvotes 10 months ago

A user shared their 9-month hair regrowth progress using Finasteride, Minoxidil, and a Derma Roller, expressing dissatisfaction with the results and considering Dutasteride. Commenters generally praised the user's results, suggesting they have a full head of hair and advising to continue the current treatment or wait longer before changing it.

community Diagnosed with female pattern hair loss as a male with recent aggressive loss. Preemptively mourning the only part of myself I’ve ever come close to loving. Lost all motivation to do anything with my life.

in Progress Pictures 271 upvotes 1 year ago

The conclusion of the conversation is that the user should consider using treatments such as finasteride, minoxidil, and RU58841 to potentially reverse their hair loss. Other suggestions include using hair loss concealers and maintaining a healthy diet.