The Rho GTPase Exchange Factor Vav2 Promotes Extensive Age-Dependent Rewiring of the Hair Follicle Stem Cell Transcriptome

    September 2023 in “ Frontiers in cell and developmental biology ”
    L. Francisco Lorenzo‐Martín, Xosé R. Bustelo
    Studysummary This study found that a catalytically active version of Vav2 significantly altered gene expression patterns in hair follicle stem cells in mice, with these changes varying over the animals' lifespans.
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    Research cited in this study 8

    1. The Rho Guanosine Nucleotide Exchange Factors Vav2 And Vav3 Modulate Epidermal Stem Cell Function Oncogene · 2022
    2. In Silico Analysis of the Age-Dependent Evolution of the Transcriptome of Mouse Skin Stem Cells Cells · 2020
    3. RhoA Promotes Epidermal Stem Cell Proliferation Via PKN1-Cyclin D1 Signaling PLoS ONE · 2017
    4. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    5. The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity Nature · 2011
    6. Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011
    7. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    8. Rac1 Is Crucial for Hair Follicle Integrity but Not Essential for Epidermis Maintenance Molecular and Cellular Biology · 2006