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Research

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research The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome

September 2023 in “Frontiers in cell and developmental biology”

This study found that a catalytically active version of Vav2 significantly altered gene expression patterns in hair follicle stem cells in mice, with these changes varying over the animals' lifespans.

research Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior

42 citations , January 2014 in “Cold Spring Harbor Perspectives in Medicine”

This abstract omits specific findings and does not provide new research results.

research Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis

25 citations , April 2021 in “The EMBO Journal”

This review discusses the role of hair follicle stem cells as active signaling centers in skin homeostasis, highlighting recent advancements and reporting no new clinical results.

Thymic Stromal Lymphopoietin Controls Hair Growth

research 751 Thymic stromal lymphopoeitin controls hair growth

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that locally administering thymic stromal lymphopoietin (TSLP) promotes hair growth by stimulating hair follicle cell proliferation during both normal conditions and after skin injury in mice.

research Clinical Efficacy of a Cosmetic Treatment by Crescina® Human Follicle Stem Cell on Healthy Males with Androgenetic Alopecia

5 citations , February 2013 in “Dermatology and therapy”

This study found that applying Crescina® HFSC lotion for four months effectively increased hair growth and reduced hair loss in males with androgenetic alopecia.

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Community Join

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community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Demystifying PP405. It is not a mystery cure with constructive criticism as a proof! It is....!!!!

1 upvotes 1 year ago

community New and Interesting HairLoss Studies/Papers/Reviews

44 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

community Why you can still look forward to PP405 and JXL-069

22 upvotes 1 month ago

PP405 and JXL-069 are the same compound, but users experienced no results due to flawed application methods. The topical gel formulation of PP405 is designed to target hair follicle stem cells effectively, unlike liquid solutions that fail to penetrate deeply.

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Learn

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learn Beta Polypeptide

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Glycerin

Can glycerin be used in combination with active ingredients like minoxidil or tretinoin? Glycerin is a common humectant that formulators treat as compatible with topical actives, but no published trial has tested it alongside minoxidil or tretinoin, so any benefit is comfort rather than a proven effect. Tretinoin is prescription-only and carries pregnancy warnings.

learn Pyrithione Zinc

Can pyrithione zinc be combined with other active ingredients like ketoconazole or minoxidil? Pyrithione zinc can be safely combined with ketoconazole and minoxidil.

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Clinics

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