Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction

    May 2021 in “ International Journal of Molecular Sciences ”
    Shun Kimura, Takashi Tsuji
    Studysummary This review discusses recent advances in scarless wound healing research, focusing on the roles of mechanobiology and immunology, and reports no new clinical results; the authors highlight the potential of next-generation human skin equivalents in understanding these mechanisms.
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    Research cited in this study 12

    1. Tissue-Scale Tensional Homeostasis in Skin Regulates Structure and Physiological Function Communications Biology · 2020
    2. Toward Understanding Scarless Skin Wound Healing and Pathological Scarring F1000Research · 2019
    3. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    4. Mechanical Forces in Skin Disorders Journal of Dermatological Science · 2018
    5. Next Generation Human Skin Constructs as Advanced Tools for Drug Development Experimental Biology and Medicine · 2017
    6. Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model Science Advances · 2016
    7. Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis Development · 2016
    8. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    9. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    10. New Hair From Healing Wounds Nature · 2007
    11. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    12. Integument Pattern Formation Involves Genetic and Epigenetic Controls: Feather Arrays Simulated by Digital Hormone Models ˜The œInternational journal of developmental biology · 2004