Re-Investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis?

    June 2018 in “ Journal of histochemistry and cytochemistry/˜The œjournal of histochemistry and cytochemistry ”
    Aki Natsumi, Koji Sugawara, Makiko Yasumizu … Daisuke Tsuruta
    Studysummary This study found that the expression of laminin-511 and -332 was significantly increased in psoriasis skin lesions and may influence keratinocyte proliferation and apoptosis, suggesting a previously overlooked role in the disease's pathogenesis.
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    Research cited in this study 4

    1. A Novel Control of Human Keratin Expression: Cannabinoid Receptor 1-Mediated Signaling Down-Regulates the Expression of Keratins K6 and K16 in Human Keratinocytes In Vitro and In Situ PeerJ · 2013
    2. Laminin-511, Inducer of Hair Growth, Is Down-Regulated and Its Suppressor in Hair Growth, Laminin-332 Up-Regulated in Chemotherapy-Induced Alopecia Journal of dermatological science · 2010
    3. Spatial And Temporal Control Of Laminin-511 And -332 Expressions During Catagen Journal of Dermatological Science · 2010
    4. Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis Genes & Development · 2008