UHPLC-Q-Orbitrap HRMS-Based Metabolomics and In Silico Studies on 5-Alpha-Reductase, JAK1, JAK2, and JAK3 of Albizia Saponaria L.: Application to Alopecia

    March 2026 in “ Tropical Journal of Natural Product Research ”
    Lukman Lukman, Noorma Rosita, Retno Widyowati
    Studysummary In this study, the bark extract of Albizia saponaria was analyzed for its metabolites and potential anti-alopecia effects, identifying several compounds with predicted affinities for proteins involved in hair loss pathways.
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    Research cited in this study 13

    1. Assessment of Antioxidant Activity, Total Phenolic and Flavonoid Contents of Albizia Saponaria L. Bark Extract Science & Technology Indonesia · 2024
    2. Minoxidil Delivered Via a Stem Cell Membrane Delivery Controlled Release System Promotes Hair Growth in C57BL/6J Mice Frontiers in Bioengineering and Biotechnology · 2024
    3. Alopecia Areata: Burden of Disease, Approach to Treatment, and Current Unmet Needs Clinical, Cosmetic and Investigational Dermatology · 2023
    4. 5-Alpha Reductase Inhibitors Use in Prostatic Disease and Beyond Translational Andrology and Urology · 2023
    5. Selective Janus Kinase 1 Inhibition Resolves Inflammation and Restores Hair Growth Offering a Viable Treatment Option for Alopecia Areata Skin health and disease · 2023
    6. Hair Aging and Hair Disorders in Elderly Patients International Journal of Trichology · 2022
    7. Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients JAMA Dermatology · 2022
    8. Hair Growth Promoting Activity of Langir Bark (Albizia Saponaria Lour.) Ethanol Extract: In Vivo Assay Rasayan journal of Chemistry · 2022
    9. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    10. Phytochemicals With Anti 5-Alpha-Reductase Activity: A Prospective For Prostate Cancer Treatment F1000Research · 2021
    11. Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride Nature Communications · 2020
    12. Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia Cosmetics · 2020
    13. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019