Treatment of MSCs with Wnt1a-Conditioned Medium Activates DP Cells and Promotes Hair Follicle Regrowth

June 2014 in “ Scientific Reports ”

Liang Dong, Haojie Hao, Lei Xia, Jiejie Liu, Dongdong Ti, Chuan Tong, Qi Hou, Qingwang Han, Yali Zhao, Huiling Liu, Xiaobing Fu, Weidong Han

Studysummary This study found that overexpression of Wnt1a in bone marrow mesenchymal stem cells enhanced mouse hair follicle regeneration and promoted hair cycling.

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The study from June 25, 2014, explored the potential of Wnt1a-conditioned medium (Wnt-CM) from bone marrow mesenchymal stem cells (BM-MSCs) to promote hair follicle regeneration. The treatment with Wnt-CM was found to accelerate the transition of hair follicles to the growth phase and increase the expression of hair induction-related genes and alkaline phosphatase (ALP) in dermal papilla (DP) cells in mice. Additionally, Wnt-CM was able to restore hair growth gene expression that had been downregulated by dihydrotestosterone (DHT) treatment. The study also showed that Wnt-CM enhanced DP cell migration, which is crucial for hair follicle development. These findings suggest that Wnt1a overexpression by BM-MSCs could be a potential therapeutic strategy for treating alopecia. The study included experiments on human DP cells and a hair regeneration model in mice, with experiments repeated three times and results showing statistical significance at P < 0.05. However, the exact number of mice or human participants was not mentioned in the summary.

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