A Novel Approach Against Male Pattern Hair Loss With Topical Dimethylglycine Sodium Salt (DMG-Na) and Caffeine: Efficacy of a 24-Week, Double-Blind, Randomized, Placebo-Controlled Trial

    August 2025 in “ Journal of Cosmetic Dermatology ”
    Leonardo Celleno, Carolina Bussoletti, Maria Vittoria Tolaini … Erik Schulze zur Wiesche
    Studysummary In this study, a DMG-Na and caffeine-containing shampoo significantly reduced hair loss and increased hair density in men with male pattern hair loss over 6 months, compared to a placebo, without adverse effects.
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    Research cited in this study 21

    1. Boosting Skin Microcirculation for Androgenetic Alopecia: Does It Work? Journal of Investigative Dermatology · 2025
    2. Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology Molecules · 2025
    3. Topically Applied N,N-Dimethylglycine Sodium Salt Enhances Human Skin Blood Flow by Inducing Endothelial Nitric Oxide Release ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2024
    4. N,N-Dimethylglycine Sodium Salt Exerts Anti-Inflammatory Effects in Dermatitis Models and Activates Human Epidermal Keratinocytes International Journal of Molecular Sciences · 2023
    5. Androgenetic Alopecia: Therapy Update Drugs · 2023
    6. Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss Journal of Clinical Medicine · 2023
    7. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    8. Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia Journal of Investigative Dermatology · 2022
    9. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    10. Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review International Journal of Molecular Sciences · 2020
    11. Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review Skin Pharmacology and Physiology · 2020
    12. Can Plant-Derived Phytochemicals Provide Symptom Relief for Hair Loss? A Critical Review International Journal of Cosmetic Science · 2019
    13. Topically Used Herbal Products for the Treatment of Hair Loss: Preclinical and Clinical Studies Archives of Dermatological Research · 2017
    14. Hair Pull Test: Evidence-Based Update and Revision of Guidelines Journal of The American Academy of Dermatology · 2016
    15. Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2013
    16. Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation Skin Pharmacology and Physiology · 2007
    17. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    18. EEMCO Guidance for the Assessment of Hair Shedding and Alopecia Skin Pharmacology and Physiology · 2004
    19. TrichoScan: A Novel Tool for the Analysis of Hair Growth In Vivo Journal of Investigative Dermatology Symposium Proceedings · 2003
    20. Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia British Journal of Dermatology · 2000
    21. Circulatory Changes in Alopecia Archives of Dermatology · 1961

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