Topically Applied N,N-Dimethylglycine Sodium Salt Enhances Human Skin Blood Flow by Inducing Endothelial Nitric Oxide Release
TLDR Applying DMG-Na to the skin increases blood flow and may help with skin conditions.
The study investigated the effects of topically applied N,N-Dimethylglycine Sodium Salt (DMG-Na) on human skin blood flow. In vitro experiments showed that DMG-Na increased intracellular calcium levels, upregulated endothelial nitric oxide synthase (eNOS) expression, and enhanced nitric oxide (NO) production in human dermal microvascular endothelial cells (HDMECs). A monocentric, single-blinded, randomized, placebo-controlled human study with 462 subjects demonstrated that a 1% DMG-Na gel significantly increased skin blood flow and velocity at both 1 mm and 8 mm depths, with no adverse effects reported. These findings suggest that DMG-Na could be beneficial for conditions like skin aging, wounds, hair loss, and various dermatitis by promoting epidermal proliferation, regeneration, and repair, and enhancing skin microcirculation. Further clinical studies are recommended to explore its potential applications.
