A Novel Approach Against Male Pattern Hair Loss With Topical Dimethylglycine Sodium Salt (DMG-Na) and Caffeine: Efficacy of a 24-Week, Double-Blind, Randomized, Placebo-Controlled Trial

The study evaluated the efficacy of a shampoo containing dimethylglycine sodium salt (DMG-Na) and caffeine for treating male pattern hair loss over 24 weeks. Involving 154 male participants, the double-blind, randomized, placebo-controlled trial showed that the active shampoo significantly reduced hair loss compared to the placebo, as evidenced by a decrease in the number of hairs pulled during a hair pull test. Secondary assessments, including subjective evaluations and phototrichogram analysis, indicated improvements in hair appearance, density, and an increased percentage of hairs in the anagen phase. The treatment was well-tolerated with no significant adverse effects, suggesting that the combination of DMG-Na and caffeine is effective in reducing hair loss and improving hair density in men with androgenetic alopecia.