Study of Association Between Valproic Acid Levels, Biotinidase Activity, and Hair Loss in Indian Population: A Cross-Sectional Comparative Study

    September 2025 in “ Indian Journal of Psychiatry ”
    Anil Kakunje, Ashwini Prabhu, Ravichandra Karkal … P. M. A. Nishad
    Studysummary This study found that individuals taking valproate had a higher incidence of hair loss and reported an association between valproate levels, reduced biotinidase activity, and hair loss, compared to a control group.
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    Research cited in this study 14

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    2. A Perspective on Predictive Markers of Alopecia Archives of Medicine and Health Sciences · 2020
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    5. Sodium Valproate Induced Alopecia: A Case Series Journal of Clinical and Diagnostic Research · 2017
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    7. Cosmetic Side Effects of Antiepileptic Drugs in Adults With Epilepsy Epilepsy & behavior · 2014
    8. Serum Drug Level-Related Sodium Valproate-Induced Hair Loss Indian Journal of Pharmacology · 2013
    9. Serum Biotinidase Activity in Children Treated With Valproic Acid and Carbamazepine Journal of child neurology · 2009
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    11. The Effects of Biotin Supplementation on Serum and Liver Tissue Biotinidase Enzyme Activity and Alopecia in Rats Treated with Valproic Acid Brain & development · 2008
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    13. Hyperactivity and Alopecia Associated with Ingestion of Valproic Acid in a Cat Journal of the American Veterinary Medical Association · 2001
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