SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis Through p53/Stem Cell Factor/C-KIT Signaling

    March 2024 in “ Journal of Investigative Dermatology ”
    Ying-Zhe Cui, Fan Xu, Yuan Zhou … Xiao‐Yong Man
    Studysummary SPRY1 deficiency in skin cells causes stem cells to move to the skin surface, leading to increased pigmentation.
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    Research cited in this study 8

    1. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    2. A Novel Mouse Model Demonstrates That Oncogenic Melanocyte Stem Cells Engender Melanoma Resembling Human Disease Nature Communications · 2019
    3. CD34 Defines Melanocyte Stem Cell Subpopulations With Distinct Regenerative Properties PLOS genetics · 2019
    4. From Neural Crest Cells to Melanocytes: Cellular Plasticity During Development and Beyond Cellular and Molecular Life Sciences · 2019
    5. Identification of Hair Shaft Progenitors That Create a Niche for Hair Pigmentation Genes & development · 2017
    6. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    7. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    8. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011