Hyaluronic Acid Hydrogel Incorporating Dexpanthenol-Engineered Extracellular Vesicles for Accelerated Wound Closure and Mitigated Secondary Infection Risk

    August 2026 in “ Pharmaceutics ”
    Hyeyoung Shin, Juwon Youn, Chang Kyu Lee … Dong Keun Han
    Studysummary In this study, researchers developed a dexpanthenol-infused nanotechnological platform within hyaluronic acid hydrogels that promoted wound healing in mice by providing a protective barrier and significantly enhancing skin regeneration, including increased fibroblast activity and tissue remodeling.
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    Research cited in this study 8

    1. Collagen-Heparin-FGF2-VEGF Scaffolds Induce a Regenerative Gene Expression Profile in a Fetal Sheep Wound Model Tissue Engineering and Regenerative Medicine · 2024
    2. Hydrogel-Mediated Extracellular Vesicles for Enhanced Wound Healing: The Latest Progress and Their Prospects for 3D Bioprinting Journal of nanobiotechnology · 2024
    3. Post-Treatment of Microneedling with a Dexpanthenol-Containing Ointment Accelerates Epidermal Wound Healing in Human 3D Skin Models Clinical Cosmetic and Investigational Dermatology · 2023
    4. Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing Stem cell research & therapy · 2023
    5. Human Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Encapsulated in Pluronic F127 Hydrogel Promote Wound Healing and Regeneration Stem Cell Research & Therapy · 2022
    6. Wound Healing: Cellular Mechanisms and Pathological Outcomes Open Biology · 2020
    7. Through the Lens of Hair Follicle Neogenesis: A New Focus on Mechanisms of Skin Regeneration After Wounding Seminars in Cell & Developmental Biology · 2019
    8. Wound Healing: A Cellular Perspective Physiological Reviews · 2018