Techniques for the Discovery and Evaluation of Drugs Against Alopecia

February 2011 in “ Expert Opinion on Drug Discovery ”

Ajay Semalty, Mona Semalty, Gopal Krishna Joshi, Mahiraj Singh Rawat

alopecia hair loss hair growth cycle in vivo models in vitro models mouse models macaque models hair length measurement histological analysis plant extracts genetically modified animal models hair growth

Studysummary This review discusses techniques and models for assessing hair growth activity but reports no new clinical findings, emphasizing the need for standardization and improved animal models.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.

research Hair Follicular Cell/Organ Culture in Tissue Engineering and Regenerative Medicine

21 citations , October 2009 in “Biochemical Engineering Journal”

This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.

research Validation of TrichoScan Technology as a Fully-Automated Tool for Evaluation of Hair Growth Parameters

38 citations , May 2009 in “European journal of dermatology/EJD. European journal of dermatology”

This study found that the TrichoScan method for evaluating hair loss showed excellent correlation with manual marking and provided more consistent, reproducible results with less variability and operator error.

research The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results

59 citations , September 2008 in “Experimental dermatology”

This study reports that C3H/HeJ mice and DEBR rats serve as effective models for screening potential treatments for human alopecia areata, despite certain challenges in predictability and cost.

research Development and Evaluation of Polyherbal Formulation for Hair Growth-Promoting Activity

67 citations , May 2007 in “Journal of Cosmetic Dermatology”

This study found that topical formulations including extracts from Cuscuta reflexa, Citrullus colocynthis, and Eclipta alba significantly accelerated hair growth initiation and completion in rats, indicating potential benefits for treating alopecia.

research Effect of Citrullus Colocynthis on Hair Growth in Albino Rats

18 citations , January 2007 in “Pharmaceutical Biology”

This study found that petroleum ether extracts of Citrullus colocynthis reduced hair growth initiation time and advanced more hair follicles to the anagen phase in albino rats compared to untreated controls and minoxidil.

research Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG)

108 citations , November 2006 in “Phytomedicine”

This study found that EGCG from green tea may stimulate human hair growth by promoting the proliferation and anti-apoptotic activity in dermal papilla cells.

research Critical Study of Hair Growth Analysis with Computer-Assisted Methods

40 citations , April 2006 in “Journal of the European Academy of Dermatology and Venereology”

This study reported that Trichoscan, a computer-assisted hair measurement system, was not supported as accurate for clinical trials due to errors in signal detection, despite its analysis speed.

research Therapeutic Strategies for Treating Hair Loss

42 citations , March 2006 in “Drug Discovery Today: Therapeutic Strategies”

This article discusses the need for rational strategies in developing hair loss drugs targeting specific events in hair follicle cycling, reporting no clinical findings but emphasizing the importance of understanding molecular controls.

Human Hair Growth Ex Vivo Is Correlated With In Vivo Hair Growth: Selective Categorization of Hair Follicles for More Reliable Hair Follicle Organ Culture

research Human Hair Growth Ex Vivo Is Correlated With In Vivo Hair Growth: Selective Categorization of Hair Follicles for More Reliable Hair Follicle Organ Culture

27 citations , November 2005 in “Archives of Dermatological Research”

This study found that selecting human hair follicles at a defined anagen stage based on their in vivo growth rate leads to more consistent results in organ culture, with minoxidil significantly enhancing hair growth in these follicles.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

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This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.

research The Hair Growth Promoting Effect of Asiasari Radix Extract and Its Molecular Regulation

87 citations , March 2005 in “Journal of Dermatological Science”

This study found that the extract of Asiasari radix may promote hair growth in mice by enhancing protein synthesis, cell proliferation, and growth factor expression.

research Evaluation and Treatment of Male and Female Pattern Hair Loss

203 citations , December 2004 in “Journal of The American Academy of Dermatology”

This article reviews the historical developments in understanding and treating male pattern hair loss, emphasizing the role of dihydrotestosterone and 5α-reductase inhibitors, but reports no new clinical findings.

research Limitations of Human Occipital Scalp Hair Follicle Organ Culture for Studying the Effects of Minoxidil as a Hair Growth Enhancer

30 citations , September 2004 in “Experimental Dermatology”

This study found that minoxidil did not significantly increase hair shaft elongation in ex vivo human hair follicle culture, questioning the suitability of this method for studying its hair-growth-promoting effects.

research The Water-Soluble Extract of Illicium Anisatum Stimulates Mouse Vibrissae Follicles in Organ Culture

25 citations , July 2004 in “Experimental Dermatology”

This study found that water-soluble extracts of Illicium anisatum promoted hair follicle elongation in cultured mouse vibrissae, suggesting potential use in hair growth products.

research In Vivo and In Vitro Evaluation of Hair Growth Potential of Hibiscus Rosa-Sinensis Linn.

128 citations , September 2003 in “Journal of Ethnopharmacology”

This study found that the petroleum ether extract from the leaves of Hibiscus rosa-sinensis demonstrated more effectiveness in promoting hair growth in rats compared to the extract from its flowers.

research The Extract of Thuja Occidentalis Semen Inhibited 5α-Reductase and Androgenetic Alopecia in B6CBAF1/J Hybrid Mice

47 citations , April 2003 in “Journal of dermatological science”

This study showed that Thujae occidentalis semen extract inhibited 5alpha-reductase type 2 in laboratory tests and reduced androgen-related hair loss in animal models, suggesting potential use for male pattern baldness.

research Stress And The Hair Follicle

61 citations , March 2003 in “American Journal Of Pathology”

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Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

research Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

194 citations , March 2003 in “American Journal of Pathology”

This study found that psychoemotional stress disrupts hair growth in mice by terminating anagen and suggests a potential pathway for pharmacological management of stress-related hair loss in humans.

research The Hair Growth Promoting Effect of Sophora Flavescens Extract and Its Molecular Regulation

75 citations , October 2002 in “Journal of Dermatological Science”

This study found that Sophora flavescens extract may promote hair growth in mice by inducing earlier hair cycle changes and regulating growth factors in dermal papilla cells.

research Causes of Hair Loss and Developments in Hair Rejuvenation

69 citations , February 2002 in “International Journal of Cosmetic Science”

This review discusses genetic and nutritional causes of hair loss, highlighting that around 90% of treated men show noticeable hair regrowth with a dual inhibitor, while women's hair loss may improve by correcting iron and l-lysine deficiencies.

research Effect of Latanoprost on Hair Growth in the Bald Scalp of the Stump-Tailed Macaque: A Pilot Study

33 citations , January 2002

This study found that daily topical application of 500 microg/ml latanoprost led to moderate to marked hair regrowth in a macaque model of androgenetic alopecia.

research Retardation of Hair Follicle Development by the Deletion of TrkC, High-Affinity Neurotrophin-3 Receptor

14 citations , September 1999 in “Journal of Investigative Dermatology”

Lack of TrkC receptor delays hair follicle development.

research Manipulation of Outer Root Sheath Cell Survival Perturbs the Hair-Growth Cycle

37 citations , July 1999 in “The EMBO Journal”

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research 13-Cis-Retinoic Acid Affects Sheath-Shaft Interactions of Equine Hair Follicles In Vitro

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research Correlation of Proteolytic Activities of Organ Cultured Intact Mouse Skin With Defined Hair Cycle Stages

28 citations , June 1994 in “Journal of Dermatological Science”

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research Potassium Channel Conductance as a Control Mechanism in Hair Follicles

30 citations , July 1993 in “Journal of Investigative Dermatology”

Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles

research Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles

12 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

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research Rat Hair Follicle Growth In Vitro

58 citations , December 1992 in “British Journal of Dermatology”

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research Alopecia Areata: A Review of Treatments and Their Efficacy

49 citations , November 1992 in “Archives of dermatology”

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research Scalp Immersion Proxigraphy: An Improved Imaging Technique for Phototrichogram Analysis

28 citations , October 1992 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

In this study, Scalp Immersion Proxigraphy (SIP) was shown to produce more accurate measurements of linear hair growth rate than crude phototrichogram techniques, suggesting SIP's suitability for clinical trials monitoring hair growth.

research Quantitative Models for the Study of Hair Growth In Vivo

34 citations , December 1991 in “Annals of the New York Academy of Sciences”

The conclusion is that small hair follicles cause baldness in macaques, and treatments like antiandrogens and minoxidil can prevent hair loss and promote regrowth.

research Hair Anatomy for the Clinician

139 citations , July 1991 in “Journal of The American Academy of Dermatology”

This article discusses the structure of hair follicles and their significance in evaluating hair disorders, but it does not report any new research findings.

research Human Hair Growth In Vitro

385 citations , November 1990 in “Journal of Cell Science”

This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.

research Biochemical Analysis of Hair Growth from the Aspects of Aging and Enzyme Activities

46 citations , February 1983 in “The Journal of Dermatology”

This study observed that hair regrowth in mice was irregular and delayed more in older mice, with increased enzyme activities in hair re-growing areas compared to non-growing areas.