20 citations
,
June 2010 in “Dermatology Online Journal” This report describes a case of hypozincemia type-II in an exclusively breast-fed infant, which resolved with zinc therapy and weaning, highlighting genetic factors in zinc transporter gene SLC30A2.
20 citations
,
August 1979 in “PubMed” This study found that adding zinc to the drinking water improved hair coat and skin condition in moustached marmosets with symptoms resembling zinc deficiency.
19 citations
,
February 2018 in “Nutrients” This review discusses the relationship between zinc deficiency and skin disorders, emphasizing zinc transporters' roles, but it reports no new clinical results; the authors highlight potential benefits of regulating zinc levels via transporters.
19 citations
,
January 2003 in “Polish Journal of Environmental Studies” This study found that women who delivered children with locomotor system malformations had significantly higher lead concentrations in their blood and hair compared to those who had healthy children.
19 citations
,
January 1974 in “Laboratory animals” In this study, inducing zinc deficiency in recently weaned female Tan rabbits led to reduced food consumption, weight loss, and reproductive issues, including inactive uterine and ovarian changes.
18 citations
,
January 1987 in “PubMed” This study found that plasma zinc concentrations were significantly lower in patients with alcoholic cirrhosis, especially those with skin manifestations of zinc deficiency, compared to control subjects.
17 citations
,
January 1981 in “International Journal of Food Sciences and Nutrition” This article reviews the roles of zinc and copper in biological processes, especially their implications for metabolism and deficiency-related disorders, but it does not present new clinical results.
16 citations
,
March 2015 in “Dermatologic therapy” This study reported two cases of alopecia areata where hair regrowth was achieved with zinc gluconate and sulfur amino acids after relapse post-PUVA cessation, suggesting potential zinc responsiveness in some patients.
16 citations
,
January 2010 in “Journal of Korean medical science/Journal of Korean Medical Science” This case report presents the first genetically confirmed case of acrodermatitis enteropathica in Korea, identifying compound heterozygous mutations in the SLC39A4 gene in an 8-month-old boy.
16 citations
,
February 1986 in “Clinica Chimica Acta” Zinc deficiency is linked to respiratory infections in children.
15 citations
,
January 2018 in “Indian Journal of Dermatology” This study reported that women with female androgenetic alopecia had significantly lower zinc levels in both serum and hair, and lower hair iron levels, compared to healthy controls.
14 citations
,
September 2021 in “International journal of molecular sciences” This review details how zinc pyrithione's anti-fungal activity makes it a successful treatment for dandruff and seborrheic dermatitis, by effectively targeting Malassezia yeast in the scalp.
14 citations
,
August 2016 in “Journal of nanomedicine research” This animal study found that biscuits fortified with zinc oxide nanoparticles improved growth, appetite, and hair growth in zinc-deficient rats more effectively than traditional zinc forms, without apparent toxicity.
14 citations
,
January 2014 in “Dermatology Research and Practice” This study observed a high incidence of transient infantile zinc deficiency among breastfeeding infants in Northern Ethiopia, but could not determine if genetic or nutritional factors or both contributed to it.
14 citations
,
October 1978 in “Archives of Dermatology” This report describes two cases where acquired zinc deficiency was associated with skin symptoms like hair loss and eczema, suggesting a recognizable syndrome in zinc-deficient patients.
13 citations
,
April 2019 in “International journal of molecular sciences” This article reviews the potential of Acyzol, a zinc-containing drug, to treat and prevent zinc deficiency conditions, but it reports no new clinical findings.
13 citations
,
January 2015 in “International Journal of Trichology” This study found that cadmium levels were significantly higher in women with chronic telogen effluvium compared to healthy controls, suggesting cadmium toxicity might contribute to this hair shedding condition.
13 citations
,
August 1982 in “PubMed” This article reviews zinc deficiency disorders, highlighting their clinical features and treatment with zinc therapy, but reports no new clinical results.
13 citations
,
March 1962 in “Nature” This study found that zinc content decreases not only in the blood but also in other tissues like the heart, spleen, liver, and kidney of carcinoma patients.
12 citations
,
June 2020 in “Crystals” This study presents a modified method for synthesizing ~1 nm zinc oxide nanoparticles within the pores of SBA-11, maintaining the mesoporous structure without requiring alcohol reflux or basic solution reaction steps.
12 citations
,
May 2017 in “Journal of pharmaceutical and biomedical analysis” In this study, researchers developed a method using scalp cyanoacrylate biopsy and advanced imaging techniques to effectively measure and visualize the distribution of anti-dandruff shampoo ingredients zinc pyrithione and climbazole within the scalp follicular infundibulum.
12 citations
,
September 1981 in “Acta Dermato Venereologica” This case study reports that oral zinc therapy improved hair growth and pigmentation in a young girl with sucrase deficiency and low zinc levels.
12 citations
,
July 1979 in “International Journal of Dermatology” This article reviews the clinical manifestations and contributing factors of acute zinc depletion syndrome, reporting no new results but discussing prevention and treatment strategies.
11 citations
,
March 2023 in “Frontiers in Nutrition” This study found that a modest increase in dietary zinc over six months resulted in a detectable increase in sulfur and zinc counts in individual hairs, suggesting a non-invasive method to monitor zinc intake effects.
11 citations
,
April 2022 in “Journal of Dermatological Treatment” This review found evidence supporting zinc use in treating infectious and inflammatory skin conditions, as well as hair loss, with supplementation recommended for zinc-deficient patients.
11 citations
,
February 2019 in “Journal of Cosmetic Dermatology” This study found that male androgenetic alopecia patients had significantly lower serum zinc levels and suboptimal biotin levels compared to healthy controls, suggesting the potential value of zinc and biotin supplementation.
11 citations
,
April 2017 in “Journal of research in pharmacy practice” This study found that the combination of zinc sulfate and calcium pantothenate improved hair density and participant satisfaction in women with hair loss, suggesting its potential as an initial treatment option.
11 citations
,
September 2010 in “PubMed” This study reports zinc and biotin deficiencies leading to hair loss and skin issues in a teenager after pancreaticoduodenectomy, highlighting the need for supplementation to prevent long-term damage.
11 citations
,
September 1999 in “Biological Trace Element Research” This study concluded that mineral element deficiencies in pregnant women may be alleviated with targeted nutrient supplementation, although mutual resistance and promotional effects among the supplements were observed.
11 citations
,
February 1990 in “PubMed” This study found that zinc treatment in alopecia areata patients may increase CD8+ cells, suggesting its effectiveness could be due to immunomodulation.