47 citations
,
April 2000 in “Experimental Dermatology” This study identified a novel missense mutation in the hairless gene in a Polish family, which may contribute to congenital atrichia with papular lesions by affecting the gene's function.
46 citations
,
May 2020 in “Cureus” This review analyzes the molecular and genetic roles of zinc, its connection to diarrheal disease, dietary recommendations, and the impacts of zinc deficiency on health, but reports no new data.
46 citations
,
November 2007 in “Gene Expression Patterns” This study observed that Trps1 gene expression in mice is precisely regulated in skin development, particularly during hair follicle morphogenesis, with distinct localization patterns in different cell types.
45 citations
,
December 1994 in “Journal of Nutrition” The type of zinc in a dog's diet affects hair growth and health.
45 citations
,
June 1984 in “Journal of the American Veterinary Medical Association” In this study, zinc supplementation rapidly improved conditions such as anorexia, depression, and foot soreness in sheep and goats diagnosed with zinc deficiency, along with healing skin lesions and resumption of hair and wool growth.
44 citations
,
May 2014 in “The American Surgeon” In this study, hair loss after laparoscopic sleeve gastrectomy was associated with zinc and iron levels, even within normal ranges, and a combined variable of zinc and iron predicted susceptibility to hair loss.
44 citations
,
November 2007 in “Journal of toxicology and environmental health. Part B, Critical reviews” This review explores how copper and zinc concentrations in hair may serve as bioindicators and discusses their potential associations with health disorders, but it reports no new clinical findings.
43 citations
,
October 2002 in “International Journal of Cosmetic Science” This study found that 1% ketoconazole and 1% piroctone olamine shampoos increased hair shaft thickness and reduced hair shedding in men with telogen effluvium and androgenic alopecia associated with dandruff.
40 citations
,
January 1973 in “Journal of Dairy Science” This study found that zinc deficiency in goats led to lower plasma zinc levels, decreased growth rate, smaller testicles, reduced libido, and was associated with higher mortality compared to control goats.
39 citations
,
July 2007 in “SKINmed Dermatology for the Clinician” In this case study, a 4-year-old girl's hair loss stopped after six months of zinc supplementation and dietary changes, suggesting a possible link to low zinc levels.
37 citations
,
March 2014 in “Journal of Trace Elements in Medicine and Biology” This study reported that Turkish males with male pattern androgenetic alopecia had significantly lower zinc and copper levels in their hair compared to healthy controls, suggesting these imbalances may play a role in the condition's etiology.
37 citations
,
August 1999 in “Journal of Investigative Dermatology” This study identified a nonsense mutation in the zinc-finger domain of the hairless gene associated with congenital atrichia in a Japanese family, indicating a potential genetic cause for this rare form of alopecia.
36 citations
,
October 2008 in “European journal of paediatric neurology” This study found that pediatric patients on valproic acid may experience hair loss due to reduced zinc and biotinidase levels within the first 3 months, with zinc depletion continuing to contribute by the 6th month.
35 citations
,
January 2006 in “Journal of Dermatological Treatment” This review found little evidence supporting zinc as a first-line treatment for dermatological conditions, except in cases of systemic zinc deficiency, and suggests further research is needed.
34 citations
,
August 2005 in “Veterinary Dermatology” This descriptive study reports that zinc deficiency in two dairy goats likely resulted from hereditary malabsorption, requiring life-long zinc supplementation to prevent skin lesions.
33 citations
,
April 2009 in “Clinical and Experimental Dermatology” This study observed that psychological factors and serum levels of zinc, folate, and vitamin B12 may contribute to the development of trichodynia.
33 citations
,
November 1999 in “The Veterinary clinics of North America. Small animal practice/Veterinary clinics of North America. Small animal practice” This review discusses zinc-responsive dermatosis and lethal acrodermatitis in dogs, noting the importance of zinc supplementation and dietary correction; it presents no new clinical findings.
32 citations
,
April 2001 in “Experimental Eye Research” Zinc is essential for healthy optic nerves, and its deficiency can damage them.
30 citations
,
June 2006 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, oral zinc sulphate was found to cause hair hypopigmentation and significantly inhibit eumelanogenesis in mice.
27 citations
,
March 2012 in “Dermatologic Therapy” In this study, all five patients with zinc deficiency-related hair loss experienced improvement or recovery of their condition after receiving oral zinc treatment.
27 citations
,
May 2010 in “Dermatologic Clinics” This review discusses the use of zinc in treating dermatological conditions and concludes that, aside from systemic zinc deficiency, its efficacy as a primary treatment is unproven, though it may be useful as a supplementary therapy.
26 citations
,
February 1978 in “Journal of Pediatric Surgery” This study found that long-term total parenteral nutrition in pediatric patients led to severe zinc deficiency, which improved with intravenous zinc therapy, highlighting the need for adequate zinc inclusion in nutritional solutions.
25 citations
,
June 1998 in “Biological Trace Element Research” This study found that young healthy women with a family history of noninsulin-dependent diabetes mellitus exhibited higher zinc and lower copper concentrations in hair compared to those without such a family history, suggesting a possible Cu-Zn antagonism.
22 citations
,
November 2010 in “Toxicological & Environmental Chemistry Reviews” In this study, higher concentrations of Pb, Cd, Cu, and Zn were found in the hair of smokers and users of hair dyes compared to non-smokers and those with undyed hair.
22 citations
,
December 1992 in “The journal of pediatrics/The Journal of pediatrics” This study reported that oral zinc therapy improved hair and skin abnormalities in patients with dry brittle hair, alopecia, and other symptoms, regardless of demonstrated zinc deficiency.
21 citations
,
June 2011 in “Journal of child neurology” This study found that while serum zinc levels were lower in children treated with valproic acid or carbamazepine than in healthy controls, zinc, biotin, and biotinidase enzyme activity remained within normal ranges and unaffected by these treatments.
21 citations
,
April 2010 in “Molecular Medicine Reports” This review discusses zinc supplementation as a complementary therapy for chronic hepatitis C, noting its potential benefits in improving treatment outcomes and reducing side effects, but reports no new clinical results.
21 citations
,
June 1983 in “Pediatric clinics of North America/The Pediatric clinics of North America” This article discusses various clinical presentations and underlying mechanisms of zinc deficiency but reports no new research findings; biochemical signs often precede clinical symptoms.
20 citations
,
June 2020 in “Journal of Advanced Research” This study found that high-dose vitamin A and E supplementation with zinc may improve glycemic control and beta-cell function in patients with type 2 diabetes, compared to no supplements.
20 citations
,
January 2014 in “Journal of Clinical & Experimental Dermatology Research” This study found that oral zinc sulphate was effective for treating patchy alopecia areata, with a low relapse rate observed after discontinuing treatment.