1 citations
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June 2013 in “Semina Ciências Agrárias” This study found that although soil and forage in Middle Paraíba, Brazil, contained normal to high copper levels, the surrounding bovine populations showed signs of copper deficiency likely due to antagonistic effects from high iron, zinc, and manganese levels.
November 2025 in “Khalij-Libya Journal of Dental and Medical Research” In this study, Libyan patients with diffuse hair loss were found to have significantly lower levels of zinc, ferritin, and vitamin D compared to those without hair loss, suggesting a possible link between these micronutrient deficiencies and hair loss.
January 2021 in “Middle East journal of applied sciences” This article discusses the widespread issue of zinc deficiency affecting plant, animal, and human health, and reports no new clinical results; the authors emphasize the need for adequate zinc availability in agriculture and nutrition.
February 2019 in “Americanae (AECID Library)” This study describes cases of diffuse alopecia and thyroid alterations in sheep, linking selenium and zinc deficiencies to decreased serum T3 and T4 concentrations and related skin conditions.
November 2022 in “Gene Cell and Tissue” This study found no significant correlation between zinc deficiency and vitamin B12 levels in blood samples from Ahvaz residents, despite some observed age-related trends in micronutrient levels.
264 citations
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January 2008 in “Journal of biomedical optics” This study found that ZnO nanoparticles in topical skin products do not penetrate beyond the outer skin layers in humans, suggesting minimal safety concerns for subdermal absorption.
246 citations
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April 1976 in “Annals of Surgery” In this study, a syndrome of zinc deficiency was observed in adults receiving intravenous feeding, with zinc supplementation improving symptoms except for delayed hair regrowth.
165 citations
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January 2014 in “Dermatology Research and Practice” This review discusses the various dermatological applications of zinc, including its use in treating infections, inflammatory dermatoses, pigmentary disorders, and neoplasias, and reports no new clinical findings.
164 citations
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September 2010 in “PLANT PHYSIOLOGY” This study found that nitric oxide production in Solanum nigrum roots facilitates adaptation to excess zinc by promoting programmed cell death and altering root architecture.
158 citations
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May 1968 in “The journal of nutrition/The Journal of nutrition” This study found that severe zinc deficiency induced in weanling rats led to growth retardation, hair issues, and dermal lesions, all of which were completely reversed by zinc supplementation.
114 citations
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October 2009 in “Gastroenterology” This review discusses zinc's role as an essential trace element in human nutrition, particularly its importance in total parenteral nutrition, and reports no new clinical results.
83 citations
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October 1998 in “The American Journal of Human Genetics” A specific gene mutation causes complete hair loss in an Irish Traveller family.
82 citations
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September 1983 in “Clinics in Gastroenterology” Zinc is vital for health, and its deficiency can worsen gastrointestinal and liver diseases.
75 citations
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May 2013 in “Journal of the American Academy of Dermatology” This review examines skin symptoms, diagnosis, and treatment of zinc deficiency in children, proposing a classification system but reporting no new clinical results.
73 citations
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January 2013 in “Annals of Dermatology” This study observed that patients with various types of hair loss had significantly lower serum zinc levels compared to healthy controls, suggesting zinc disturbance may play a role in the condition.
73 citations
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May 1976 in “JAMA” This case report associates severe zinc deficiency with long-term total parenteral nutrition, suggesting the need for trace element supplementation in such nutritional management.
72 citations
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September 1975 in “Biology of Reproduction” This study found that zinc is primarily located in the tails of mature rat sperm, associated with -S-S-bonded structures, and suggests a possible similarity in zinc interactions between sperm keratin and hair proteins.
70 citations
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March 1980 in “Journal of Nutrition” Zinc deficiency in monkeys causes skin issues and reproductive problems, but supplementation reverses these effects.
68 citations
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February 1996 in “Obesity Surgery” This study found that significant hair loss in about one-third of patients after vertical gastroplasty was reversed by zinc supplementation.
65 citations
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January 2009 in “Annals of Dermatology” In this study, oral zinc supplementation for twelve weeks increased serum zinc levels in alopecia areata patients with low zinc, showing positive hair regrowth in 66.7% of participants, though this was not statistically significant.
60 citations
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October 2005 in “Experimental Dermatology” This study found that high-dose oral zinc significantly influences hair growth in mice, showing both inhibition and promotion effects depending on the timing and duration of administration.
59 citations
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October 2017 in “Proceedings of the National Academy of Sciences” This study found that the zinc transporter ZIP10 is crucial for epidermal development, as it influences the activity of p63, promoting epidermal morphogenesis.
57 citations
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January 2004 in “Journal of Radiation Research” This study found that zinc supplementation reduced the severity and delayed the onset of radiation-induced skin injury in rats, with the greatest protection observed at a dose of 10 mg/kg/day.
56 citations
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January 2013 in “International journal of trichology” This case report suggests that zinc supplements may be necessary to improve hair loss in hypothyroidism patients being treated with thyroxine.
54 citations
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June 2001 in “The Indian Journal of Pediatrics” This study found that newborns with neural tube defects and their mothers had significantly lower hair zinc levels compared to controls.
53 citations
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October 1978 in “Archives of dermatology” This study reports two cases of acquired zinc deficiency presenting with skin symptoms such as hair loss and acrodermatitis, suggesting these manifestations may help in diagnosing zinc deficiency in humans.
53 citations
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January 1953 in “The journal of nutrition/The Journal of nutrition” This study found that newborn mice deprived of colostrum developed disorders linked to zinc deficiency, and administering inorganic zinc prevented these conditions.
52 citations
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July 2015 in “International Journal of Dermatology” This study found that patients with alopecia areata had significantly lower serum zinc levels, which correlated inversely with disease severity, duration, and resistance to therapies, suggesting zinc assessment as a marker of disease status.
50 citations
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November 1984 in “Journal of Heredity” This study found that supplementing zinc improved certain developmental defects in mice with the lethal-milk mutation, although it did not increase the survival rate among backcross progeny.
49 citations
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January 1991 in “Food and chemical toxicology” In this study, zinc chloride was found to be severely irritant to the skin in rabbit, guinea-pig, and mouse models, while zinc oxide, zinc sulphate, zinc pyrithione, and zinc undecylenate showed minimal to no irritancy.