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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.

Red light at 627 nm can safely trigger IL-4 release in skin cells, potentially helping treat inflammatory skin conditions.

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

Finasteride may help reduce inappropriate sexual behaviors in dementia patients with prostate issues.

Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.

Different light affects cell functions and can help treat skin conditions.

COX2 and ATP synthase control the size of hedgehog spines.

KRT17 may be a new target for endometrial cancer treatment because it helps cancer cells move and form new blood vessels.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Fat tissue-derived cells show promise for repairing body tissues, but more research and regulation are needed for safe use.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

Low-oxygen conditions and ECM degradation products increase the healing abilities of perivascular stem cells.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.