173 citations
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January 2014 in “Nature Cell Biology” Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.
113 citations
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June 2015 in “Stem Cell Research & Therapy” Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
66 citations
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July 2015 in “Organogenesis” Wnt signaling is crucial for skin wound healing and reducing scars.
48 citations
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July 2008 in “Acta Biochimica et Biophysica Sinica” Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.
45 citations
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July 2016 in “Journal of Dermatological Science” The Wnt/β-catenin pathway can activate melanocyte stem cells and may help regenerate hair follicles.
43 citations
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September 2017 in “Lasers in Surgery and Medicine” LED light therapy may help hair growth by activating certain cell pathways.
29 citations
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May 2020 in “npj Regenerative Medicine” Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.
18 citations
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July 2016 in “Medicine” Wnt/β-catenin and TGF-β pathways affect hair loss, and activating Wnt/β-catenin could be a potential treatment.
March 2024 in “Vestnik Rossijskogo universiteta družby narodov. Seriâ Agronomiâ i životnovodstvo” Wnt and Shh signaling are key in noggin-induced tumors, and blocking them can slow tumor growth.
June 2015 in “Journal of Investigative Dermatology” Wnt-3a helps grow more skin stem cells, which could lead to new hair loss treatments.
May 2018 in “Journal of Investigative Dermatology” Activating Wnt in skin cells controls the number of hair follicles by directing cell movement and fate.
56 citations
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February 2010 in “PLOS ONE” Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.
47 citations
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January 2017 in “Molecular and Cellular Endocrinology” Androgens prevent hair growth by changing Wnt signals in cells.
32 citations
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July 2012 in “Stem Cells Translational Medicine” Vitamin D3 can help improve hair growth by enhancing the function of specific skin cells and could be useful in hair regeneration treatments.
10 citations
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January 2020 in “Seminars in Cell & Developmental Biology” Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.
20 citations
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December 2016 in “Journal of Cosmetic Dermatology” Methyl vanillate spray increases hair count and hair mass in women with hair loss.
17 citations
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April 2011 in “Journal of Investigative Dermatology” Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.
13 citations
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March 2018 in “Plastic and Reconstructive Surgery” The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.
8 citations
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November 2017 in “Journal of Investigative Dermatology” CXXC5 is a protein that prevents hair growth and could be a target for hair loss treatment.
6 citations
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April 2017 in “Frontiers in Pharmacology” Chinese medicine may help treat hair loss by affecting genes and enzyme activity.
August 2012 in “Nature Cell Biology” A pathway helps maintain long telomeres in both stem and cancer cells.
43 citations
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November 2009 in “Journal of Cellular and Molecular Medicine” TGF-β2 plays a key role in human hair growth and development.
29 citations
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May 2010 in “Journal of Dermatological Science” Wnt3a activates certain genes in hair follicle cells, including a newly discovered one, EP2, which may affect hair growth.
23 citations
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January 2020 in “Frontiers in Pharmacology” Dihydrotestosterone affects hair growth by changing the Wnt/β-catenin pathway, with low levels helping and high levels hindering growth.
20 citations
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February 2020 in “Stem Cells” Hes1 protein is important for hair growth and regeneration, and could be a potential treatment for hair loss.
March 2024 in “Cytologia” LncRNA MTC boosts growth of goat skin cells, improving cashmere quality.
95 citations
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May 2012 in “British Journal of Dermatology” Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.
59 citations
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May 2016 in “Cell Reports” EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.
51 citations
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March 2014 in “Nature Communications” Skin tumor regression is helped by retinoic acid signaling blocking Wnt signaling.
25 citations
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September 2018 in “Scientific Reports” Morroniside may help hair grow and stay in its growth phase by affecting certain cell signals.