30 citations
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January 2009 in “Nuclear Receptor Signaling” This study identified the Hairless (Hr) gene-encoded protein as a corepressor that plays a crucial role in maintaining skin and hair by regulating epithelial stem cell differentiation and gene expression via chromatin remodeling, which may impact both development and disease.
2 citations
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June 1997 in “The American Journal of Cosmetic Surgery” This article discusses methods for camouflaging surgical sites after hair transplant procedures and presents no new clinical findings.
This study found that WISP-1 plays a key role in ligamentum flavum fibrosis through the Hedgehog-Gli1 pathway, with cyclopamine showing potential to reduce fibrosis effects in a rabbit model.
January 2024 in “Biochemistry Research International” This study found that compounds from Ziziphus spina-christi roots exhibited promising antibacterial and antioxidant activities, supporting its traditional medicinal use.
10 citations
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November 2018 in “Nature Biotechnology” Drugmakers are optimistic about targeting the Wnt pathway for new treatments despite past challenges.
3 citations
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January 2019 in “Therapeutic advances in urology” This review concluded that WS PRO 160 I 120 mg, a herbal preparation, may be an effective and safer alternative to standard drugs for treating lower urinary tract symptoms in men with benign prostatic hyperplasia.
21 citations
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October 2022 in “International Journal of Molecular Sciences” This study found that quercitrin, a natural compound, enhances Wnt/β-catenin signaling and may help mitigate synapse loss and memory impairment in Alzheimer's models.
July 2024 in “Journal of Investigative Dermatology” JW0061 may be a new treatment for hair loss by promoting hair growth through WNT signaling.
January 2026 in “Frontiers in Pharmacology” This review highlights the potential of wedelolactone from the plant Wedelia Chinensis, summarizing its reported pharmacological effects, including anti-inflammatory, antiviral, antibacterial, antitumor, anti-osteoporosis activities, and organ protection based on existing in vitro and in vivo research findings.
13 citations
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August 2020 in “Frontiers in Cell and Developmental Biology” This study found that Twist1 and Tcf4 synergistically regulate the hair follicle induction ability of dermal papilla cells by forming a complex with β-catenin, enhancing their biological properties.
9 citations
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September 2018 in “Journal of Photochemistry and Photobiology B-biology” This study demonstrated that combining l-cystine and thiamin in a formulation may protect against UV-induced damage in growth-limited human epidermal keratinocytes in vitro.
4 citations
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January 2011 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study demonstrated that vitamin B12 may promote hair growth in vitro by modulating intracellular signaling in the wnt-pathway, suggesting potential benefits for micrograft transplantation.
3 citations
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January 2023 in “Agriculture and Natural Resources” This study found that flower extracts of Wedelia trilobata may serve as a promising active ingredient for cosmeceutical products due to their antioxidant, anti-inflammatory, and antimicrobial properties.
This study found that Clitocybin A from Clitocybe aurantiaca may promote hair growth in immortalized rat dermal papilla cells by enhancing cell proliferation and activating Wnt/β-catenin signaling and ERK pathways.
July 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” New treatment with Wnt proteins and growth factors safely increases hair thickness.
36 citations
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June 2021 in “Experimental & Molecular Medicine” This study found that mechanical stress activates a WISP-1/Hedgehog signaling axis that contributes to ligamentum flavum hypertrophy and fibrosis, identifying Hedgehog signaling as a potential therapeutic target.
April 2025 in “Drug Design Development and Therapy” This study observed that the herbal extract WJWE promoted hair growth and protected hair follicle cells in a DHT-induced murine model of androgenetic alopecia, potentially by engaging the SIRT1/JNK/p38 MAPK and Wnt5A/β-Catenin signaling pathways.
April 2006 in “Dermatologic Clinics” This study found that white wax and its extract significantly promoted hair growth in a mouse model of androgenetic alopecia, outperforming finasteride by inhibiting 5α-reductase activity and enhancing cellular proliferation.
March 2026 in “Communications Biology” This study identified nine compounds that activate Wnt signaling, with aminoacridine and proflavine especially promoting hair and nail regeneration in mouse models, highlighting new therapeutic candidates from existing FDA-approved and natural compounds.
May 2025 in “Experimental Dermatology” In this study, researchers developed a novel genetic tool using Wif1-CreER knock-in mice for precise labeling and manipulation of dermal papilla cells, which could enhance understanding of hair biology and aid in developing targeted therapies for hair-related disorders.
March 2023 in “JIIS (Jurnal Ilmiah Ibnu Sina): ilmu farmasi dan kesehatan” This study concluded that the optimum biotin microemulsion hair tonic composition involves span 80 (20%), tween 80 (9.47%), and PEG 400 (5%), providing favorable viscosity and globule size.
April 2023 in “Journal of Investigative Dermatology” In this study, Aminoacridine, Abemaciclib, and the combination of Aminoacridine with Minoxidil showed potential for effective hair regeneration by activating Wnt/β-catenin signaling in animal experiments.
April 2024 in “Journal of microbiology and biotechnology” The authors will correct the table to show the right antibody information.
6 citations
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November 2022 in “Journal of Tissue Engineering and Regenerative Medicine” This study found that while zebularine did not significantly accelerate wound healing, it improved the quality of restored skin in mice, suggesting potential for further research into epigenetic inhibitors.
41 citations
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August 2015 in “The FASEB Journal” The researchers reported that topical application of small-molecule Wnt inhibitors significantly reduced fibrosis and promoted regenerative wound healing in mice.
5 citations
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January 1991 in “Drugs of The Future” January 2026 in “Frontiers in Pharmacology” This study found that anwuligan, an active ingredient in BaoHeWan, may promote hair regeneration in mice by activating the Wnt/β-catenin signaling pathway and enhancing hair follicle cell proliferation.
July 2026 in “Journal of Investigative Dermatology”
27 citations
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July 2017 in “Scientific Reports” This study found that conditional knockout of N-WASP in keratinocytes of mice led to skin barrier defects, increased immune cell infiltration, and hyperproliferation of keratinocytes, indicating its crucial role in skin homeostasis.
28 citations
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December 2008 in “Laboratory investigation” This study observed that selectively activating activin in the epidermis of mice enhanced reepithelialization during wound healing without altering the quality of the healed wound.