Wedelolactone, A Natural Coumestan With Multiple Pharmacological Effects

    January 2026 in “ Frontiers in Pharmacology ”
    Shanshan Han, Minghe Li, Longfei Yang, Xinming Zhuang
    Studysummary This review highlights the potential of wedelolactone from the plant Wedelia Chinensis, summarizing its reported pharmacological effects, including anti-inflammatory, antiviral, antibacterial, antitumor, anti-osteoporosis activities, and organ protection based on existing in vitro and in vivo research findings.
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    Research cited in this study 8

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    2. Assessment of the Chemical Profile and Potential Medical Effects of a Flavonoid-Rich Extract of Eclipta Prostrata L. Collected in the Central Highlands of Vietnam Pharmaceuticals · 2023
    3. The Potential Role of Herbal Extract Wedelolactone for Treating Particle-Induced Osteolysis: An In Vivo Study Journal of Orthopaedic Surgery and Research · 2022
    4. Wedelolactone Attenuates Pulmonary Fibrosis Partly Through Activating AMPK and Regulating Raf-MAPKs Signaling Pathway Frontiers in Pharmacology · 2019
    5. Wedelolactone Inhibits Breast Cancer-Induced Osteoclastogenesis by Decreasing Akt/mTOR Signaling International Journal of Oncology · 2014
    6. Ethnopharmacological Significance of Eclipta Alba (L.) Hassk. (Asteraceae) International Scholarly Research Notices · 2014
    7. Wedelolactone, A Medicinal Plant-Derived Coumestan, Induces Caspase-Dependent Apoptosis In Prostate Cancer Cells Via Downregulation Of PKCε Without Inhibiting Akt International Journal of Oncology · 2012
    8. Hair Growth Promoting Activity of Eclipta Alba in Male Albino Rats Archives of Dermatological Research · 2008