56 citations,
September 2010 in “Veterinary pathology” Certain mouse strains develop a skin condition similar to a human hair loss disease due to genetic defects.
48 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Contact sensitizers like DCP and SADBE are the most effective treatments for alopecia areata.
44 citations,
January 2013 in “BMC Dermatology” TGFβ signaling prevents sebaceous gland cells from producing fats.
39 citations,
June 2019 in “Nanomaterials” Nanotube-based hair treatments could improve hair health and growth, and offer long-lasting effects.
33 citations,
May 2016 in “Translational andrology and urology” Laser hair removal before genital surgery can prevent complications and improve patient satisfaction.
22 citations,
January 2020 in “Veterinary dermatology” The conclusion is that certain dog and cat breeds are prone to Malassezia dermatitis, which can be diagnosed with skin tests and treated with antifungal shampoos or medications, and preventing relapses involves managing underlying issues and maintaining good hygiene.
18 citations,
June 2019 in “Clinical research in dermatology” Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.
18 citations,
August 2019 in “Nutrients” Eating barley for life may lead to healthier aging in mice.
14 citations,
January 2018 in “Skin Appendage Disorders” Upper eyelid hyperpigmentation can help diagnose facial lichen planus pigmentosus in patients with frontal fibrosing alopecia.
13 citations,
December 2012 in “Medical mycology case reports” Misdiagnosis led to permanent hair loss, stressing the need for proper scalp tests.
11 citations,
June 2017 in “Asian-Australasian journal of animal sciences” Fox genes are important for hair growth and development in cashmere goats.
8 citations,
April 2016 in “Experimental dermatology” B6.Cg-Tyr c−2J Hr hr /J mice have a stronger delayed sunburn reaction and are good for UV research.
7 citations,
March 2021 in “Journal of the American Academy of Dermatology” Tofacitinib can regrow hair in alopecia areata patients, but some may experience flares during treatment.
5 citations,
May 2023 in “Science of the total environment” PFAS exposure in adolescence may delay puberty in females.
5 citations,
January 2020 in “The mental health clinician” Vitamin D supplements may reduce hair-pulling in people with Trichotillomania.
3 citations,
April 2022 in “Frontiers in Physiology” Ptch2 plays a key role in controlling stem cell function and the ability to regenerate after birth.
3 citations,
September 2021 in “BioEssays” Dandruff might be caused by changes in how hair follicles naturally release oils and an immune response to this imbalance.
1 citations,
November 2023 in “iScience” A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.
1 citations,
December 2022 in “BMC Plant Biology” The black orchid Brasiliorchis schunkeana produces chemicals that attract certain insects and have potential antimicrobial properties.
May 2024 in “Journal of medicinal food” Jojoba oil has many uses beyond skincare, including health benefits and pharmaceutical applications.
April 2024 in “Applied biological chemistry” Piperine from black pepper can make hair less oily by blocking fat cell development in hair roots.
October 2024 in “Cosmoderma” Proper hair care and suitable products are essential for men's scalp health and well-being.
September 2024 in “Journal of Cosmetic Dermatology” Follow these guidelines to safely and effectively use energy-based devices in aesthetic treatments.
September 2023 in “Pharmaceutics” The new face mask with Eflornithine can potentially reduce facial hair growth and moisturize skin.
489 citations,
November 2021 in “Signal Transduction and Targeted Therapy” The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.
219 citations,
January 2006 in “Drug Metabolism Reviews” DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.
179 citations,
June 2000 in “The American journal of pathology” The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.
161 citations,
August 2012 in “Seminars in cell & developmental biology” Hair growth and development are controlled by specific signaling pathways.
153 citations,
April 1998 in “Current Biology” The study investigated the effects of expressing a mutant H-ras oncogene in different epidermal cell types in mice, revealing that targeting hair follicle cells led to the development of benign skin tumors that often progressed to malignant squamous and spindle carcinomas. This contrasted with previous findings where expression in interfollicular cells did not lead to spontaneous malignancy. The study involved 464 animals, with 30% developing skin tumors, highlighting the significant influence of the targeted cell type on the malignant potential of tumors, with hair follicle cells being a primary source of tumors at high risk of malignant conversion.
140 citations,
February 2014 in “Neuron” The study revealed that delta opioid receptors (DOR) played a crucial role in regulating cutaneous mechanosensation, including touch, by inhibiting synaptic input to the spinal dorsal horn through blocking voltage-gated calcium channels. DOR was primarily expressed in large-diameter, myelinated mechanoreceptors, challenging previous beliefs about its expression in small-diameter neurons. The research used a DORGFP knockin mouse model to map DOR distribution and found that DOR agonists like deltorphin II significantly reduced neurotransmitter release, suggesting a potential target for treating injury-induced mechanical hypersensitivity. The study highlighted the distinct roles of DOR and mu opioid receptors (MOR) in somatosensory processing, with DOR affecting mechanoreceptors involved in touch sensation and MOR associated with nociceptive pathways. These findings provided insights into the molecular mechanisms by which opioids could modulate touch and pain sensations.