Associations Of Prenatal And Postnatal Exposure To Perfluoroalkyl Substances With Pubertal Development And Reproductive Hormones In Females And Males: The Home Study

    May 2023 in “ Science of the total environment ”
    Yun Liu, Antònia M. Calafat, Aimin Chen, Bruce P. Lanphear, Nana‐Hawa Yayah Jones, Kim M. Cecil, Susan R. Rose, Kimberly Yolton, Jessie P. Buckley, Joseph M. Braun
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    Studysummary This study observed that higher PFAS concentrations during adolescence were linked to later pubertal development and lower estradiol levels in females, but not in males, potentially due to PFAS excretion with menstrual fluid.
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    The study investigated the associations of prenatal and postnatal exposure to perfluoroalkyl substances (PFAS) with pubertal development and reproductive hormones in 200 children from the HOME Study. The results showed that higher adolescent PFAS concentrations were consistently associated with delayed pubertal development and menarche in females, but not in males. Additionally, higher PFAS levels in adolescence were linked to lower estradiol levels in females. The study suggests that larger studies are needed to confirm these findings and to determine if these associations are independent of puberty-induced pharmacokinetic changes.
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