Ptch2 Is a Potential Regulator of Mesenchymal Stem Cells

April 2022 in “ Frontiers in Physiology ”

Emma Juuri, Pauli Tikka, Andrii Domanskyi, Ian J. Corfe, Wataru Morita, Peter J. McKinnon, Nela Jandova, Anamaria Balic

Ptch2 Hedgehog signaling pathway mesenchymal stem cells Ptch1 Gli1 stem cell function regenerative capacity differentiation potential skin

TLDR Ptch2 plays a key role in controlling stem cell function and the ability to regenerate after birth.

The study "Ptch2 is a Potential Regulator of Mesenchymal Stem Cells" found that Ptch2, a receptor in the Hedgehog signaling pathway, plays a significant role in regulating stem cell function and postnatal regenerative capacity. The absence of Ptch2 in mutant mice led to changes in tissues where Ptch2 is co-expressed with Ptch1, affecting the mesenchymal stem cells (MSCs) and their regenerative and differentiation potential. This was observed in the teeth, long bones, and skin of the mice. The study also found that Ptch2 regulates Hh signaling mainly through the Gli1 protein. Therefore, Ptch2 is a critical regulator of stem cell function and postnatal regenerative capacity.

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